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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Cognitive improvement after HCV eradication: Extending the benefits
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Cognitive improvement after HCV eradication: Extending the benefits

机译：消除HCV后的认知改善：扩大收益

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摘要

A direct effect of the hepatitis C virus (HCV) on the central nervous system (CNS) was proposed over 10 years ago as a mechanism for the neu-rocognitive impairment reported in this infection. A number of studies have shown impairments in working memory, attention, executive function, and processing speed in patients with noncirrhotic HCV infection. However, despite the many patients treated in the last decade, there have been no published studies on the effect of successful antiviral treatment on neurocogni-tive function in large prospectively studied cohorts. Over this period, alpha-interferon has remained the backbone of antiviral regimens and the CNS effects of this administered cytokine have been intensively studied during treatment.
机译：十多年前，丙型肝炎病毒（HCV）对中枢神经系统（CNS）产生了直接影响，被认为是该感染中报道的中枢认知障碍的一种机制。多项研究表明，非肝硬化HCV感染患者的工作记忆，注意力，执行功能和处理速度均受到损害。然而，尽管在最近十年中接受了许多患者的治疗，但尚未有关于成功进行抗病毒治疗对大量前瞻性研究人群的神经认知功能影响的公开研究。在此期间，α-干扰素一直是抗病毒方案的基础，在治疗过程中已深入研究了这种给药的细胞因子的中枢神经系统作用。

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