With great interest, we read the article by Speliotes et al., who studied a large community-based sample from the Framingham Heart Study and reported that fatty liver is associated with dyslipidemia and dysglycemia independendy of visceral fat. Interestingly, the study demonstrated an association between fatty liver and increased blood pressure. Even though the mechanisms underlying this association may be complicated, we hypothesize that elevated uric acid levels potentially link fatty liver and high blood pressure on the basis of the risk relationships between hyperuricemia and chronic liver disease/hypertension.
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