...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Nucleotide-binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis.
【24h】

Nucleotide-binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis.

机译：包含2个（NOD2）变体的核苷酸结合寡聚域是肝硬化中死亡和自发性细菌性腹膜炎的遗传危险因素。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Spontaneous bacterial peritonitis (SBP), a severe complication in patients with advanced liver cirrhosis, has been attributed to bacterial translocation from the intestine. Variants of the NOD2 (nucleotide-binding oligomerization domain containing 2) gene have been associated with impaired mucosal barrier function in Crohn disease. We hypothesized that the risk of acquiring SBP is increased in patients with cirrhosis carrying NOD2 variants. We recruited 150 nonselected patients with liver cirrhosis and ascites admitted to our unit, monitored survival, and recorded the development of SBP prospectively and retrospectively. SBP was defined as the presence of polymorphonuclear neutrophil (PMN) cells >250 per microL of ascitic fluid. Patients were genotyped for the NOD2 variants p.R702W, p.G908R, and c.3020insC. During a median follow-up of 155 days, 54 patients (36%) died and SBP was diagnosed in 30 patients (20%). The occurrence of SBP was increased significantly (P = 0.008) in carriers of NOD2 variants (odds ratio [OR] = 3.06). Retrospectively, SBP was observed in 22 additional patients, and the combined prospective and retrospective analysis substantiated the association between NOD2 and SBP (P = 0.004; OR = 2.98). Of note, carriers of NOD2 risk alleles showed a significantly (P = 0.007) reduced mean survival time (274 days) in comparison to patients with wildtype genotypes (395 days). Conclusion: Common NOD2 variants linked previously to impaired mucosal barrier function may be genetic risk factors for death and SBP. These findings might serve to identify patients with cirrhotic ascites eligible for preemptive antibiotic treatment.
机译：自发性细菌性腹膜炎（SBP）是晚期肝硬化患者的严重并发症，其原因是细菌从肠道移位。在克罗恩病中，NOD2（含有2个核苷酸的寡核苷酸结合域）基因的变异与粘膜屏障功能受损有关。我们假设携带NOD2变异的肝硬化患者获得SBP的风险增加。我们招募了150名未入选的肝硬化和腹水患者，纳入我们的病房，监测其生存率，并前瞻性和回顾性记录SBP的进展。 SBP被定义为每微升腹水中存在250个以上的多形核中性粒细胞（PMN）细胞。对患者的NOD2变体p.R702W，p.G908R和c.3020insC进行基因分型。在155天的中位随访期间，有54例患者（36％）死亡，并且有30例患者（20％）被诊断为SBP。在NOD2变异的携带者中，SBP的发生显着增加（P = 0.008）（比值[OR] = 3.06）。回顾性地，在另外22例患者中观察到SBP，前瞻性和回顾性分析相结合证实了NOD2和SBP之间的相关性（P = 0.004; OR = 2.98）。值得注意的是，与具有野生型基因型的患者（395天）相比，具有NOD2风险等位基因的携带者显示平均生存时间（274天）显着减少（P = 0.007）。结论：以前与黏膜屏障功能受损有关的常见NOD2变异可能是死亡和SBP的遗传危险因素。这些发现可能有助于确定有资格进行抢先抗生素治疗的肝硬化腹水患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号