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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Antituberculosis therapy drug-induced liver injury and acute liver failure.
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Antituberculosis therapy drug-induced liver injury and acute liver failure.

机译：抗结核治疗药物性肝损伤和急性肝衰竭。

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摘要

We read with great interest the study by Kumar et al., who reported antituberculosis therapy (ATT) as the only cause of drug-induced acute liver failure (ALF) in northern India, in contrast to antimicrobials, anticonvulsants, and paracetamol in the West2" and in southern India.Our experience with drug-induced liver injury (DILI), including injury due to ATT, from 1997 to 2008 at the Department of Gastroenterology of St. John's Medical College Hospital (Bangalore, India) offers something in support of their findings and something at odds.7 Table 1 outlines the clinical and biochemical characteristics of all patients with DILI due to ATT. Kumar et al. found a mortality rate of 67% among 70 patients (mean age = 32 years) with ATT-caused ALF; most (63%) were treated empirically for tuberculosis.
机译：我们非常感兴趣地阅读了Kumar等人的研究，他们报告说抗结核疗法（ATT）是印度北部药物诱发的急性肝衰竭（ALF）的唯一原因，与西方的抗菌剂，抗惊厥药和扑热息痛相反2在印度南部。我们从1997年至2008年在印度圣约翰医学院附属医院胃肠病科（印度班加罗尔）进行的药物诱发性肝损伤（DILI）（包括ATT损伤）方面的经验提供了一些支持7表1概述了所有因ATT导致的DILI患者的临床和生化特征，Kumar等人发现70例由ATT引起的患者（平均年龄= 32岁）的死亡率为67％ ALF;大多数（63％）经验性治疗结核病。

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