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Bladder Preservation Strategies

机译:膀胱保存策略

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摘要

Although cystectomy remains the standard for treatment of muscle-invasive bladder cancer in the United States, there exist potentially curative alternatives for a selected subset of these patients in organ preservation using concurrent chemotherapy with radiation following an aggressive transurethral resection of the tumor. Chemotherapy and radiotherapy in combination, with salvage cystectomy for invasive recurrence, have produced 10-year disease-specific survival rates of 60% to 65% with overall survival similar to that of cystectomy in selected patients. Fine-tuning of the chemoradiotherapy sequencing, timing, and fractionation has been reported in both singlecenter and cooperative group publications from North America and Europe.
机译:尽管在美国,膀胱切除术仍然是治疗肌肉浸润性膀胱癌的标准,但是对于这些患者中的一部分患者,在进行积极的经尿道切除术后同时进行放化疗并放化疗的情况下,对于这些患者的选定亚组存在潜在的治疗选择。化学疗法和放疗疗法结合挽救性膀胱切除术用于有创性复发,已经产生了10年疾病特异性生存率,从60%到65%不等,总体生存率与某些患者的膀胱切除术相似。在北美和欧洲的单中心和合作小组出版物中均已报道了对放化疗序列,时间和分级的微调。

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