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首页> 外文期刊>Hematology/Oncology Clinics of North America >Chronic myelogenous leukemia: role of stem cell transplant in the imatinib era.
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Chronic myelogenous leukemia: role of stem cell transplant in the imatinib era.

机译:慢性粒细胞性白血病:伊马替尼时代干细胞移植的作用。

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摘要

In the pre-tyrosine kinase (TKI) era, allogeneic stem cell transplant (allo-SCT) was the front-line treatment of choice for young patients with chronic myelogenous leukemia (CML). Today, imatinib is well established as front-line therapy for CML, with excellent long-term outcomes. This has changed the role of allo-SCT and the number of patients undergoing allo-SCT has declined dramatically. Allo-SCT is currently recommended for patients in accelerated/blast phase disease, those who have failed a second-generation TKI and those with TKI-resistant mutations such as T315I. The role of allo-SCT in the management of CML will require continual reappraisal as medical therapies continue to evolve.
机译:在酪氨酸激酶前(TKI)时代,同种异体干细胞移植(allo-SCT)是年轻的慢性粒细胞性白血病(CML)患者的一线治疗选择。如今,伊马替尼已被广泛确立为CML的一线治疗方法,具有长期良好的疗效。这改变了异源SCT的作用,接受异源SCT的患者数量急剧下降。目前建议将Allo-SCT用于加速/疾患疾病,第二代TKI失败的患者以及具有TKI耐药性突变的患者,例如T315I。随着医学疗法的不断发展,allo-SCT在CML管理中的作用将需要不断的重新评估。

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