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Study-design selection criteria in systematic reviews of effectiveness of health systems interventions and reforms: A meta-review

机译：对卫生系统干预措施和改革的有效性进行系统评价的研究设计选择标准：荟萃评价

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摘要

At present, there exists no widely agreed upon set of study-design selection criteria for systematic reviews of health systems research, except for those proposed by the Cochrane Collaboration's Effective Practice and Organisation of Care (EPOC) review group (which comprises randomized controlled trials, controlled clinical trials, controlled before-after studies, and interrupted time series). We conducted a meta-review of the study-design selection criteria used in systematic reviews available in the McMaster University's Health Systems Evidence or the EPOC database. Of 414 systematic reviews, 13% did not indicate any study-design selection criteria. Of the 359 studies that described such criteria, 50% limited their synthesis to controlled trials and 68% to some or all of the designs defined by the EPOC criteria. Seven out of eight reviews identified at least one controlled trial that was relevant for the review topic. Seven percent of the reviews included either no or only one relevant primary study. Our meta-review reveals reviewers' preferences for restricting synthesis to controlled experiments or study designs that comply with the EPOC criteria. We discuss the advantages and disadvantages of the current practices regarding study-design selection in systematic reviews of health systems research as well as alternative approaches.
机译：目前，除Cochrane协作组织有效实践和护理组织（EPOC）审查小组（包括随机对照试验，对照的临床试验，对照的前后研究以及中断的时间序列）。我们对麦克马斯特大学医疗系统证据或EPOC数据库中可用的系统评价中使用的研究设计选择标准进行了元评价。在414篇系统评价中，有13％未表明任何研究设计选择标准。在描述此类标准的359项研究中，有50％将其合成限于对照试验，而68％则限于EPOC标准定义的某些或全部设计。 8篇评论中有7篇确定了至少一项与该评论主题相关的对照试验。 7％的评论不包含或仅包含一项相关的基础研究。我们的元审查揭示了审查者偏爱将合成限制为符合EPOC标准的受控实验或研究设计。我们在卫生系统研究的系统评价以及替代方法中讨论了有关研究设计选择的当前实践的优缺点。

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