...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hepatology international >Comparison of effects of hepatitis E or A viral superinfection in patients with chronic hepatitis B.
【24h】

Comparison of effects of hepatitis E or A viral superinfection in patients with chronic hepatitis B.

机译：慢性乙型肝炎患者中戊型或甲型病毒重叠感染的效果比较。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: To compare the demographics, liver function, and prognosis of Chinese patients infected with chronic hepatitis B (CHB) and superinfected with hepatitis E virus (HEV) or hepatitis A virus (HAV). PATIENTS AND METHODS: Among 188 patients with CHB, 136 with HEV superinfection and 52 with HAV superinfection were treated at our hospital between March 1999 and October 2007 for clinical features suggestive of acute hepatitis. The patients' age, sex, incidence of liver failure, and mortality were recorded. The tested biochemical indices and markers of liver function included serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), prothrombin activity (PTA), and the serum levels of HBeAg, HBeAb, and HBV DNA. RESULTS: There were significant differences between the age and sex distributions of the two groups (P < 0.05). More patients in the CHB + HEV group had complications (94.9 vs. 61.5%, P < 0.001), and hepatic failure (39.7 vs. 11.5%, P = 0.002). Additionally, the mortality among the CHB + HEV group was significantly higher (33.8 vs. 1.9%, P < 0.001). CONCLUSIONS: The comparison of clinical outcomes revealed that patients with HBV + HEV had more advanced baseline liver disease and a poorer prognosis than those with HBV + HAV. Because there is no vaccine against HEV, patients with CHB should take appropriate precautions against superinfection with HEV, such as consumption of boiled water and well-cooked food, in regions where it is endemic.
机译：目的：比较中国感染慢性乙型肝炎（CHB）和重感染戊型肝炎病毒（HEV）或甲型肝炎病毒（HAV）的中国患者的人口统计学，肝功能和预后。患者与方法：在1999年3月至2007年10月间，我院对188例CHB患者中的136例HEV重叠感染和52例HAV重叠感染进行了治疗，以提示急性肝炎的临床特征。记录患者的年龄，性别，肝衰竭发生率和死亡率。测试的肝功能生化指标和标志物包括血清丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），总胆红素（TBil），凝血酶原活性（PTA）以及血清HBeAg，HBeAb和HBV DNA水平。结果：两组的年龄和性别分布存在显着差异（P <0.05）。 CHB + HEV组中有更多患者发生并发症（94.9 vs. 61.5％，P <0.001）和肝功能衰竭（39.7 vs. 11.5％，P = 0.002）。此外，CHB + HEV组的死亡率显着更高（33.8 vs. 1.9％，P <0.001）。结论：临床结果的比较显示，与HBV + HAV相比，HBV + HEV患者有更高的基线肝病和预后较差。由于没有针对HEV的疫苗，因此CHB患者应在地方性流行地区采取适当的预防措施，以防止HEV过度感染，例如饮用白开水和煮熟的食物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号