...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hemodialysis international >Association of blood pressure with all-cause mortality and stroke in Japanese hemodialysis patients: The Japan dialysis outcomes and practice pattern study
【24h】

Association of blood pressure with all-cause mortality and stroke in Japanese hemodialysis patients: The Japan dialysis outcomes and practice pattern study

机译：血压与日本血液透析患者的全因死亡率和中风的关联：日本透析结果和实践模式研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The association of low blood pressure (BP) with high mortality is a characteristic for hemodialysis patients. This analysis clarifies the association of BP with mortality and stroke in Japanese hemodialysis (HD) patients and examines the association separately for patients with and without antihypertensive medication (BP meds). We analyzed 9134 patients from Japan in phases 1-4 (1999-2011) of the Dialysis Outcomes and Practice Patterns Study (DOPPS), a prospective cohort study of in-center HD patients. The association of patient systolic (SBP) and diastolic (DBP) blood pressure with all-cause and cause-specific mortality was assessed using adjusted Cox regression. A U-shaped association between BP and all-cause mortality was observed, with lowest mortality for baseline SBP 140-159mmHg and DBP 65-74mmHg. Both SBP and DBP were positively and monotonically associated with stroke-related death: hazard ratio (95% confidence interval) was 1.24 (1.01-1.53) per 20mmHg higher SBP and 1.23 (1.05-1.44) per 10mmHg higher DBP. No evidence of interaction was found between SBP and use of BP meds regarding all-cause mortality (P for interaction=0.97); the association between SBP and stroke-related death was slightly stronger among patients not on BP meds than patients on BP meds (P for interaction=0.09). In Japanese HD patients, both low and high BP are associated with all-cause mortality. This analysis also documents a positive and monotonic association of BP with stroke-related deaths. Although our analysis indicates that the prescription of BP meds to hypertensive patients might protect against stroke-related death, additional study is warranted.
机译：低血压（BP）与高死亡率的关联是血液透析患者的特征。该分析阐明了日本血液透析（HD）患者的BP与死亡率和中风的相关性，并分别检查了是否使用抗高血压药物（BP meds）的患者。我们在透析结果和实践模式研究（DOPPS）的第1-4期（1999-2011年）中对9134名来自日本的患者进行了分析，这是一项针对中心HD患者的前瞻性队列研究。使用调整后的Cox回归评估了患者收缩压（SBP）和舒张压（DBP）与全因和特定原因死亡率的关联。观察到BP与全因死亡率之间呈U型关联，基线SBP 140-159mmHg和DBP 65-74mmHg的死亡率最低。 SBP和DBP均与中风相关的死亡呈正相关关系：危险比（95％置信区间）为每增加20mmHg SDB 1.24（1.01-1.53​​）和每增加10mmHg DBP 1.23（1.05-1.44）。没有发现在SBP和使用BP meds有关全因死亡率之间存在相互作用的证据（相互作用P = 0.97）;与未服用BP药物的患者相比，未服用BP药物的患者的SBP与中风相关死亡之间的关联性稍强（相互作用P = 0.09）。在日本HD患者中，低和高BP均与全因死亡率相关。该分析还记录了BP与卒中相关死亡之间存在正向和单调的联系。尽管我们的分析表明，高血压患者的BP药物处方可能会预防中风相关的死亡，但仍需要进行进一步的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号