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首页> 外文期刊>Histopathology: Official Journal of the British Division of the International Academy of Pathology >Reduced expression of αGlcNAc in Barrett's oesophagus adjacent to Barrett's adenocarcinoma - a possible biomarker to predict the malignant potential of Barrett's oesophagus
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Reduced expression of αGlcNAc in Barrett's oesophagus adjacent to Barrett's adenocarcinoma - a possible biomarker to predict the malignant potential of Barrett's oesophagus

机译：邻近Barrett腺癌的Barrett食管中αGlcNAc的表达降低-可能是预测Barrett食道恶性潜能的生物标志物

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Aims: Gastric gland mucin contains O-glycans exhibiting terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc). Recently we demonstrated that mice deficient in αGlcNAc in gastric gland mucin develop gastric adenocarcinoma spontaneously, indicating that αGlcNAc is a tumour suppressor for gastric cancer. However, the role of αGlcNAc in Barrett's oesophagus (BO) remains unknown. In this study, we investigated whether reduced αGlcNAc expression in BO is associated with development of Barrett's adenocarcinoma (BAC). Methods and results: Thirty-five BO lesions adjacent to BAC were examined by immunohistochemistry for αGlcNAc, MUC6 and CDX2. As controls, 35 BO lesions without BAC obtained from patients with oesophageal squamous cell carcinoma were also analysed. Expression of αGlcNAc relative to its scaffold MUC6 in BO adjacent to BAC was reduced significantly compared to control BO. Decreased αGlcNAc expression in BO adjacent to BAC was particularly significant in patients with smaller tumour size (<20 mm) and minimal invasion of tumour cells to the superficial muscularis mucosae. There was also a significant inverse correlation between αGlcNAc and CDX2 expression in BO adjacent to BAC. Conclusions: Decreased expression of αGlcNAc compared with MUC6 in BO is a possible hallmark in predicting BAC development.
机译：目的：胃粘蛋白含有O-聚糖，具有末端α1,4-连接的N-乙酰氨基葡糖残基（αGlcNAc）。最近，我们证明了缺乏胃腺粘蛋白中的αGlcNAc的小鼠自发地发展为胃腺癌，这表明αGlcNAc是胃癌的肿瘤抑制因子。然而，αGlcNAc在巴雷特食管（BO）中的作用仍然未知。在这项研究中，我们调查了BO中αGlcNAc表达降低是否与Barrett腺癌（BAC）的发展有关。方法和结果：通过免疫组织化学检查了35例邻近BAC的BO病变中的αGlcNAc，MUC6和CDX2。作为对照，还分析了食管鳞状细胞癌患者获得的35例无BAC的BO病变。与对照BO相比，αGlcNAc相对于其支架MUC6的表达在与BAC相邻的BO中显着降低。在肿瘤较小（<20 mm）且肿瘤细胞对肌层粘膜的侵袭极少的患者中，与BAC相邻的BO中αGlcNAc表达的降低尤为显着。在邻近BAC的BO中，αGlcNAc和CDX2表达之间也存在显着的负相关。结论：与MUC6相比，BO中αGlcNAc的表达降低可能是预测BAC发展的标志。

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