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首页> 外文期刊>Hippocampus >Metabolic activity in the brain of juvenile and adult rats with a neonatal ventral hippocampal lesion.
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Metabolic activity in the brain of juvenile and adult rats with a neonatal ventral hippocampal lesion.

机译：新生腹侧海马病变的幼年和成年大鼠脑中的代谢活性。

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Longitudinal studies on patients for schizophrenia suggest that functional brain perturbations precede the onset of symptoms. Rats with a neonatal ventral hippocampal lesion (NVHL) are considered as a heuristic neurodevelopmental model of schizophrenia. We characterized basal metabolic changes observed in NVHL rats before and after the age when known behavioral alterations have been reported. Male pups were lesioned with ibotenic acid at postnatal day 7 (PD7). We measured local cerebral metabolic rates for glucose (LCMRglc) by the quantitative autoradiographic [(14)C]2-deoxyglucose technique at pre- (PD21) and postpubertal (PD42) ages when NVHL rats do not express abnormal dopamine related behaviors, and at adulthood (PD70). We observed a widespread increase in LCMRglcs in PD21 NVHL indicative of an ongoing intense reorganization of the brain while at PD42, increases were less extended. At PD70, changes in glucose metabolism were restricted to specific systems, such as the auditory system, the cerebellum, the serotonergic median raphe, and median septum. These data show in a heuristic animal model of schizophrenia that functional metabolic changes within the brain could precede the onset of dopamine-related behavioral alterations and lead to a distinct ensemble of functional changes in adulthood in systems that may be relevant to schizophrenia.
机译：对精神分裂症患者的纵向研究表明，功能性脑动荡先于症状发作。患有新生腹侧海马病变（NVHL）的大鼠被视为精神分裂症的启发式神经发育模型。我们报道了已知行为改变后年龄前后在NVHL大鼠中观察到的基础代谢变化。在出生后第7天（PD7），雄性幼崽被异丁酸损害。我们通过定量放射自显影[（14）C] 2-脱氧葡萄糖技术在NVHL大鼠未表现出异常多巴胺相关行为的前（PD21）和青春期（PD42）年龄测量了局部大脑的葡萄糖代谢水平（LCMRglc）。成年（PD70）。我们观察到PD21 NVHL中LCMRglcs的广泛增加，表明大脑正在进行持续的强烈重组，而在PD42处，增加的幅度较小。在PD70，葡萄糖代谢的变化被限制在特定的系统中，例如听觉系统，小脑，血清素能中位数缝隙和中隔。这些数据在精神分裂症的启发式动物模型中显示，大脑内的功能性代谢变化可能早于多巴胺相关的行为改变的发作，并导致成年期与精神分裂症相关的系统功能变化明显整合。

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