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首页> 外文期刊>HNO >Tissue engineering using porous polyethylene implants [Tissue-Engineering mit por?sen Polyethylenimplantaten]
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Tissue engineering using porous polyethylene implants [Tissue-Engineering mit por?sen Polyethylenimplantaten]

机译:使用多孔聚乙烯植入物的组织工程学[组织工程学MIT聚乙烯亚甲基戊酸酯]

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摘要

Although porous polyethylene (PPE) implants are already used in reconstructive craniofacial surgery, they are still only applied in rhinoplasty when critically indicated. Biocompatibility of PPE implants (pore size ~100-200 μm) can be modified by tissue engineering: coatings with extracellular matrix components, growth factors, anti-inflammatory substances and living cells are all possible. At present, transparent dorsal skinfold chamber models in animals appear to be particularly appropriate for pre-clinical evaluation. Using in vivo fluorescence microscopy, angiogenic microvascular ingrowth and inflammatory leukocyte-endothelial cell interactions can be analysed in detail with regard to functionally relevant mechanical integration. Preclinical data indicate that tissue engineering could improve the biocompatibility of these novel PPE implants and thus extend their range of clinical applications.
机译:尽管多孔聚乙烯(PPE)植入物已经用于重建性颅面外科手术中,但在有严格指征时仍仅用于隆鼻。 PPE植入物(孔径约100-200μm)的生物相容性可以通过组织工程进行改进:具有细胞外基质成分,生长因子,抗炎物质和活细胞的涂层都是可能的。目前,动物的透明背皮腔室模型似乎特别适合临床前评估。使用体内荧光显微镜,可以在功能上相关的机械整合方面详细分析血管生成性微血管向内生长和炎性白细胞-内皮细胞的相互作用。临床前数据表明,组织工程可以改善这些新型PPE植入物的生物相容性,从而扩大其临床应用范围。

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