A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents.

Agarwal A; Srivastava K; Puri SK; Sinha S; Chauhan PM

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A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents.

机译：一个三取代的嘧啶小文库，可作为抗疟和抗结核药。

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A small library of 20 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activities. Out of the total screened compounds, 16 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25-2microg/mL and 8 compounds have shown antitubercular activity against Mycobacterium tuberculosis H(37)Ra, at a concentration of 12.5microg/mL.

机译：合成了一个由20个三取代的嘧啶组成的小文库，并对其体外抗疟和抗结核活性进行了评估。在全部筛选出的化合物中，有16种化合物对恶性疟原虫的体外抗疟活性为0.25-2microg / mL，8种化合物对结核分枝杆菌H（37）Ra的抗结核活性为12.5microg / mL。毫升

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《Bioorganic and Medicinal Chemistry Letters》 |2005年第23期|共4页
作者
Agarwal A; Srivastava K; Puri SK; Sinha S; Chauhan PM;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Pyrimidines; Libraries; /mL; In Vitro; Antitubercular Agents; 嘧啶类; 图书馆; 抗结核药;

机译：Pyrimidines;Libraries;/mL;In Vitro;Antitubercular Agents;嘧啶类;图书馆;抗结核药;

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1. A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents. [J] . Agarwal A, Srivastava K, Puri SK, Bioorganic and Medicinal Chemistry Letters . 2005,第23期

机译：一个三取代的嘧啶小文库，可作为抗疟和抗结核药。
2. Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. [J] . Hans RH, Wiid IJ, van Helden PD, Bioorganic and Medicinal Chemistry Letters . 2011,第7期

机译：新型硫代内酯-靛红杂种作为潜在的抗疟药和抗结核药。
3. Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. [J] . Hans RH, Wiid IJ, van Helden PD, Bioorganic and Medicinal Chemistry Letters . 2011,第7期

机译：新型硫代内酯-靛红杂种作为潜在的抗疟药和抗结核药。
4. In Silico Screening of the Library of Pyrimidine Derivatives as Antitubercular agent [C] . Gopinathan N., K. Chitra International Conference on Bioinformatics and Computational Biology . 2012

机译：在嘧啶衍生物文库中作为抗细胞剂的硅筛选
5. Part I. Design, synthesis and biological evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents. Part II. Development of novel taxoid-based drug conjugates and theranostic imaging agents towards tumor-targeted chemotherapy. [D] . Park, Bora. 2014

机译：第一部分：针对FtsZ作为抗结核药的新型2,5,6-三取代苯并咪唑的设计，合成和生物学评估。第二部分新型基于紫杉醇的药物结合物和治疗诊断剂在肿瘤靶向化疗中的应用。
6. SAR Studies on Trisubstituted Benzimidazoles as Inhibitors of Mtb FtsZ for the Development of Novel Antitubercular Agents [O] . Divya Awasthi, Kunal Kumar, Susan E. Knudson, -1

机译：SAR研究三取代苯并咪唑作为Mtb FtsZ抑制剂开发新型抗结核药的研究
7. Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials [O] . Norcross Neil R., Baragana Beatriz, Wilson Caroline, 2016

机译：三取代嘧啶类有效且速效的抗疟药
8. 2-Hydroxymethylcyclopropyl- Idenemethylpurines and - Pyrimidines as Antiviral Agents. [R] . Zemlicka, J., Qiu, Y. L., Drach, J. C., 2005

机译：2-羟甲基环丙基 - Idenemethylpurines和 - 嘧啶作为抗病毒剂。

A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents.

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