Rapamycin analogs with reduced systemic exposure.

Wagner R; Mollison KW; Liu L; Henry CL; Rosenberg TA; Bamaung N; Tu N; Wiedeman PE; Or Y; Luly JR; Lane BC; Trevillyan J; Chen YW; Fey T; Hsieh G; Marsh K; Nuss M; Jacobson PB; Wilcox D; Carlson RP; Carter GW; Djuric SW

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Rapamycin analogs with reduced systemic exposure.

【24h】

Rapamycin analogs with reduced systemic exposure.

机译：雷帕霉素类似物具有降低的全身暴露。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared with rapamycin.

机译：报道了在C-40位修饰的雷帕霉素（I）类似物的合成和生物学活性。重点放在由于与雷帕霉素相比具有较短的体内半衰期而可能具有改善的安全性的化合物上。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2005年第23期|共4页
作者
Wagner R; Mollison KW; Liu L; Henry CL; Rosenberg TA; Bamaung N; Tu N; Wiedeman PE; Or Y; Luly JR; Lane BC; Trevillyan J; Chen YW; Fey T; Hsieh G; Marsh K; Nuss M; Jacobson PB; Wilcox D; Carlson RP; Carter GW; Djuric SW;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Sirolimus; analogs; Systemic; in vivo; Carbon ion;

机译：西罗莫司;类似物;全身;体内;碳离子;

相似文献

外文文献
中文文献
专利

1. Rapamycin analogs with reduced systemic exposure. [J] . Wagner R, Mollison KW, Liu L, Bioorganic and Medicinal Chemistry Letters . 2005,第23期

机译：雷帕霉素类似物具有降低的全身暴露。
2. Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior [J] . Fushen Zhang, Shihao Huang, Haiyan Bu, Frontiers in Neuropharmacology . 2021,第a期

机译：通过雷帕霉素的MTOR激酶的全身抑制破坏重新溶解，降低了可卡因寻求行为
3. Local therapeutic efficacy with reduced systemic side effects by rapamycin-loaded subcapsular microspheres [J] . Falke Lucas L., van Vuuren Stefan H., Kazazi-Hyseni Filis, Biomaterials . 2015,第Null期

机译：载雷帕霉素的包膜下微球降低了局部疗效，减少了系统性副作用
4. STRATEGIES TO ENHANCE THE NEUROPROTECTIVE PROPERTIES OF RAPAMYCIN ANALOGS [C] . Guy T. Carter Proceedings of Functional Molecules from Natural Sources . 2011

机译：增强雷帕霉素类似物的神经保护性能的策略
5. An evaluation of the efficacy of domestic allergen-avoidance: Using vacuum cleaners with high-efficiency exhaust filtration to reduce fungal exposure and impermeable bedding encasements to reduce dust -mite exposure. [D] . Recer, Gregg M. 2002

机译：对避免家庭变应原功效的评估：使用具有高效排气过滤功能的真空吸尘器，以减少真菌的暴露；不渗透的床上用品包裹，以减少尘螨的暴露。
6. Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior [O] . Fushen Zhang, Shihao Huang, Haiyan Bu, 2021

机译：通过雷帕霉素通过全身抑制MTOR激酶破坏重新溶解降低了寻求可卡因的行为
7. Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior [O] . Fushen Zhang, Shihao Huang, Haiyan Bu, 2021

机译：通过雷帕霉素通过全身抑制MTOR激酶破坏重新溶解，降低了寻求可卡因的行为

Rapamycin analogs with reduced systemic exposure.

摘要

著录项

相似文献

相关主题

期刊订阅