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首页> 外文期刊>Chemphyschem: A European journal of chemical physics and physical chemistry >Microarray-Basecl in vitro Evaluation of DNA Oligomer Libraries Designed in silico
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Microarray-Basecl in vitro Evaluation of DNA Oligomer Libraries Designed in silico

机译：基于芯片的Basecl体外设计的计算机设计DNA低聚物文库

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We report on the microarray-based in vitro evaluation of two libraries of DNA oligonucleotide sequences, designed in silico for applications in supramolecular self-assembly, such as DNA computing and DNA-based nanosciences. In this first study which is devoted to the comparison of sequence motif propteris theoretically predicted with their performance in real-life, the DNA-directed immobilization (DDI) of proteins was used as an example of DNA-base self-assembly. Since DDI technologies, DNA computing, and DNA nanoconstruction essentially depend on similar prerequisites, in particular, large and uniform hybridization efficiencies combined with low nonspecific cross-reactivity between individual sequences, we anticipate that the microarray approach demonstrated here will enable rapid evaluation of other DNA sequence libraries.
机译：我们报告了基于DNA的两个寡核苷酸序列文库的体外评估，这些文库是计算机设计的，用于超分子自组装，例如DNA计算和基于DNA的纳米科学。在这项致力于理论上比较序列基序属性及其在现实生活中的性能的研究中，蛋白质的DNA定向固定（DDI）被用作DNA碱基自组装的一个例子。由于DDI技术，DNA计算和DNA纳米结构基本上取决于相似的先决条件，尤其是大而均匀的杂交效率以及各个序列之间的低非特异性交叉反应性，因此我们期望此处展示的微阵列方法能够快速评估其他DNA序列库。

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