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首页> 外文期刊>Trends in Ecology & Evolution >POSITIVE SELECTION AND RECOMBINATION - MAJOR MOLECULAR MECHANISMS IN COLICIN DIVERSIFICATION [Review]
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POSITIVE SELECTION AND RECOMBINATION - MAJOR MOLECULAR MECHANISMS IN COLICIN DIVERSIFICATION [Review]

机译:积极的选择和重组-大分子机理在大肠菌素多样化中的作用[综述]

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摘要

Colicins, a family of antimicrobial proteins produced by Escherichia coli, are one of the best characterized microbial systems for studying processes of molecular diversification. Recent studies employing DNA sequence comparisons and experimental evolution suggest that positive selection and recombination play dominant roles in colicin diversification. Recombination between distantly related colicins has repeatedly generated novel classes of colicins, while positive selection for novel colicin immunity systems produces further diversity among closely related colicins. Together, these forces have resulted in a surprisingly large and diverse class of antimicrobials. Colicins are thought to play an important role in the invasion of bacteria into novel habitats. [References: 31]
机译:Colicins是由大肠杆菌生产的一系列抗菌蛋白,是研究分子多样化过程中最具特色的微生物系统之一。使用DNA序列比较和实验进化的最新研究表明,阳性选择和重组在大肠菌素多样化中起主要作用。远距离相关的大肠菌素之间的重组反复产生了新型的大肠菌素,而对新型大肠菌素免疫系统的积极选择在密切相关的大肠菌素之间产生了进一步的多样性。这些力量共同导致了令人惊讶的大类多样的抗菌剂。人们认为,colicins在细菌入侵新的栖息地中起着重要作用。 [参考:31]

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