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首页> 外文期刊>Trends in Endocrinology and Metabolism: TEM >G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation.
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G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation.

机译：G蛋白偶联受体和酪氨酸激酶：细胞信号传导和调节的十字路口。

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摘要

G-protein-coupled receptors and protein tyrosine kinases represent two prominent pathways for cellular signaling. As our knowledge of cell signaling pathways mediated by the superfamily of G-protein-coupled receptors and the smaller family of receptor tyrosine kinases expands, so does our appreciation of how these two major signaling platforms share information and modulate each other, otherwise termed "cross-talk". Cross-talk between G-protein-coupled receptors and tyrosine kinases can occur at several levels, including the receptor-to-receptor level, and at crucial downstream points (e.g. phosphatidylinositol-3-kinase, Akt/protein kinase B and the mitogen-activated protein kinase cascade). Regulation of G-protein-coupled receptors by non-receptor tyrosine kinases, such as Src family members, also operates in signaling. A broader understanding of how G-protein-coupled receptors and tyrosine kinases cross-talk reveals new insights into signaling modalities in both health and disease.
机译：G蛋白偶联受体和蛋白酪氨酸激酶代表细胞信号转导的两个主要途径。随着我们对由G蛋白偶联受体的超家族和较小的受体酪氨酸激酶家族介导的细胞信号转导途径的了解不断扩展，我们对这两个主要信号转导平台如何共享信息和相互调节的认识也在不断提高，否则称为“交叉-谈论”。 G蛋白偶联受体与酪氨酸激酶之间的串扰可能发生在几个水平，包括受体到受体的水平以及关键的下游点（例如磷脂酰肌醇3激酶，Akt /蛋白激酶B和促细胞分裂剂活化的蛋白激酶级联）。非受体酪氨酸激酶（例如Src家族成员）对G蛋白偶联受体的调节也可在信号传导中发挥作用。对G蛋白偶联受体和酪氨酸激酶如何相互作用的更广泛理解揭示了对健康和疾病信号传导方式的新见解。

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