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首页> 外文期刊>Trends in Genetics >Histone variants and cellular plasticity
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Histone variants and cellular plasticity

机译：组蛋白变体和细胞可塑性

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The broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular signals and the DNA is the chromatin, a dynamic nucleoprotein complex that helps to mediate gene regulation. The most basic subunit of chromatin, the nudeosome, consists of DNA wrapped around histones, a set of proteins that play crucial roles as scaffolding molecules and regulators of gene expression. Growing evidence indicates that canonical histones are commonly replaced by protein variants before and during cellular transitions. We highlight exciting new results suggesting that histone variants are essential players in the control of cellular plasticity during development and in the adult nervous system.
机译：通过将内在的细胞信息与发育和其他外在信号相结合，脊椎动物内细胞类型的广泛多样性源自独特的遗传蓝图。染色质位于细胞信号与DNA的界面，是一种动态的核蛋白复合物，有助于介导基因调控。染色质的最基本亚基，即核糖体，由包裹在组蛋白周围的DNA组成，组蛋白是一组蛋白质，它们在脚手架分子和基因表达调节剂中起着至关重要的作用。越来越多的证据表明，典型的组蛋白通常在细胞转变之前和过程中被蛋白质变体取代。我们强调了令人兴奋的新结果，表明组蛋白变异体是发育过程中和成人神经系统中控制细胞可塑性的重要参与者。

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