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首页> 外文期刊>Human Genetics >The origins and genetic structure of three co-resident Chinese Muslim populations: the Salar, Bo'an and Dongxiang.
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The origins and genetic structure of three co-resident Chinese Muslim populations: the Salar, Bo'an and Dongxiang.

机译：三个共同居住的中国穆斯林人口的起源和遗传结构：撒拉族，博安族和东乡族。

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A genome-based investigation of three Muslim populations, the Salar, Bo'an, and Dongxiang, was conducted on 212 individuals (148 males, 64 females) co-resident in Jishisan County, a minority autonomous region located in the province of Gansu, PR China. The Salar are believed to be of Turkic origin, whereas the Bo'an and Dongxiang both speak Mongolian. Biparental dinucleotide markers on chromosomes 13 and 15 indicated elevated mean homozygosity in the Salar (0.32), Bo'an (0.32), and Dongxiang (0.27), equivalent to inbreeding coefficients ( F(is) ) of 0.16; 0.12; 0.01, confirming varying levels of endogamous and consanguineous marriage in all three communities. Y-chromosome unique event polymorphisms (UEPs) showed that males in the three communities shared common ancient origins, with 80-90% of haplotypes in common. However, the high levels of community-specific Y-chromosome STR haplotypes strongly suggested the action(s) of founder effect, genetic drift and preferential consanguinity during more recent historical time. By comparison with the marked inter-community differentiation revealed by the Y-chromosome STRs (29.4%), the mtDNA data indicated similarity between the female lineages of each community with just 1.2% inter-community variation. The combined use of these different marker systems gives an in-depth historical perspective, and provides evidence of past inter-marriage between genetically diverse male founders of each community and Han Chinese females with subsequent community endogamy.
机译：对位于甘肃省少数民族自治地区吉士山县的212名共同居住的穆斯林（撒拉族，博安族和东乡族）进行了基于基因组的调查，共212人（男148例，女64例）。中国公关。撒拉人被认为起源于突厥，而博安和东乡都说蒙古语。 13号和15号染色体上的双亲双核苷酸标记表明，撒拉族（0.32），博安族（0.32）和东乡族（0.27）的平均纯合度升高，相当于近交系数（F（is））为0.16; 0.12; 0.01，证实了所有三个社区的内婚和近亲婚姻水平不同。 Y染色体独特事件多态性（UEP）显示，三个社区中的男性具有共同的古老起源，其中80-90％的单体型是共同的。然而，高水平的社区特异性Y染色体STR单倍型强烈暗示了在最近的历史时期中，创始人效应，遗传漂移和优先血缘的作用。通过与Y染色体STRs显着的社区间差异（29.4％）进行比较，mtDNA数据表明每个社区的女性谱系之间具有相似性，而社区间差异仅为1.2％。这些不同标记系统的结合使用提供了深入的历史视角，并提供了每个社区遗传多样性不同的男性创始人与汉族女性以及随后的社区内婚制之间过去婚姻的证据。

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