Dog Models for Blinding Inherited Retinal Dystrophies

Simon M. Petersen-Jones Andras M. Komaromy

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Dog Models for Blinding Inherited Retinal Dystrophies

机译：盲遗传性视网膜营养不良的狗模型

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Spontaneous canine models exist for several inherited retinal dystrophies. This review will summarize the models and indicate where they have been used in translational gene therapy trials. The RPE65 gene therapy trials to treat childhood blindness are a good example of how studies in dogs have contributed to therapy development. Outcomes in human clinical trials are compared and contrasted with the result of the preclinical dog trials.

机译：存在几种遗传性视网膜营养不良的自发犬模型。这篇综述将总结这些模型，并指出它们在转化基因治疗试验中的使用位置。 RPE65基因疗法用于治疗儿童失明症的试验是狗研究如何促进疗法发展的一个很好的例子。将人类临床试验的结果与临床前狗试验的结果进行比较和对比。

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《Human gene therapy. Clinical development》 |2015年第1期|共12页
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Simon M. Petersen-Jones Andras M. Komaromy;
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1. Dog Models for Blinding Inherited Retinal Dystrophies [J] . Simon M. Petersen-Jones Andras M. Komaromy Human gene therapy. Clinical development . 2015,第1期

机译：盲遗传性视网膜营养不良的狗模型
2. Organization of the canine gene encoding the E isoform of retinal guanylate cyclase (cGC-E) and exclusion of its involvement in the inherited retinal dystrophy of the Swedish Briard and Briard-beagle dogs. [J] . Veske A, Nilsson SE, Gal A Biochimica et biophysica acta: international journal of biochemistry and biophysics . 1998,第1期

机译：编码视网膜鸟苷酸环化酶E异构体（cGC-E）的犬基因的组织，并排除了它参与瑞典Briard和Briard-beagle狗的遗传性视网膜营养不良的情况。
3. Identifying variation in models of care for the genomic-based diagnosis of inherited retinal dystrophies in the United Kingdom [J] . Eden M., Payne K., Jones C., Eye . 2016,第7期

机译：识别英国基于基因组诊断遗传性视网膜营养不良的护理模型的变异
4. Reducing the artifacts in the identification of outer retinal boundary in the SD-OCT image with inherit retinal dystrophies [C] . Min Zhang, Sekiguchi Hiroyuki, Uji Akihito, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2015

机译：减少具有遗传性视网膜营养不良的SD-OCT图像中识别外部视网膜边界的伪影
5. Exploring miRnas as Modulators in Retinal Degeneration: Potential Therapeutic Tools for Inherited Retinal Dystrophies [D] . Guadagnino, Irene. 2021

机译：视网膜退化中的调节剂探索miRNA：遗传性视网膜营养不良的潜在治疗工具
6. Dog Models for Blinding Inherited Retinal Dystrophies [O] . Simon M. Petersen-Jones, András M. Komáromy -1

机译：盲遗传性视网膜营养不良的狗模型
7. Organization of the canine gene encoding the E isoform of retinal guanylate cyclase (cGC-E) and exclusion of its involvement in the inherited retinal dystrophy of the Swedish Briard and Briard–Beagle dogs [O] . Veske Andres, Nilsson Sven Erik G, Gal Andreas 1998

机译：编码鸟嘌呤鸟苷酸环化酶E亚型的犬基因的组织，并排除了其参与瑞典Briard和Biard-Beagle犬遗传性视网膜营养不良的原因

Dog Models for Blinding Inherited Retinal Dystrophies

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