Antigen-specific regulatory T-cell subsets in transplantation tolerance regulatory T-cell subset quality reduces the need for quantity.

Koenen HJ; Joosten I

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Antigen-specific regulatory T-cell subsets in transplantation tolerance regulatory T-cell subset quality reduces the need for quantity.

机译：移植耐受性调节性T细胞亚群质量中的抗原特异性调节性T细胞亚群减少了数量需求。

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Regulatory T cells (Treg) are critical controllers of the immune response. Disturbed Treg function results in autoimmunity, whereas in transplantation Treg are crucial in graft survival and transplant tolerance. Hence therapeutic modalities that influence Treg numbers or function hold great clinical opportunity. Ahead of us are clinical trails studying in vivo Treg induction protocols and immunotherapy with ex vivo expanded Treg. Here we discuss the preferential use and/or induction of antigen-specific Treg subsets with high suppressive power and migratory capacity as a potential therapeutic tool to prevent solid organ transplantation rejection. Accordingly, ex vivoselection procedures to induce and isolate highly suppressive antigen-specific Treg (subsets) are needed. This subject, as well as the Treg-facilitating potential of immunosuppressive agents, is discussed.

机译：调节性T细胞（Treg）是免疫反应的关键控制者。 Treg功能紊乱会导致自身免疫，而在移植中Treg对移植物存活和移植耐受性至关重要。因此，影响Treg数量或功能的治疗方式具有巨大的临床机会。我们前进的是研究体内Treg诱导方案和离体扩增Treg免疫疗法的临床试验。在这里，我们讨论具有高抑制能力和迁移能力的抗原特异性Treg亚型的优先使用和/或诱导，以作为预防实体器官移植排斥的潜在治疗工具。因此，需要用于诱导和分离高度抑制性抗原特异性Treg（亚群）的离体选择程序。讨论了该主题以及免疫抑制剂促进Treg的潜力。

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《Human Immunology: Official Journal of the American Society for Histocompatibility and Immunogenetics》 |2006年第9期|共11页
作者
Koenen HJ; Joosten I;
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正文语种 eng
中图分类基础医学;
关键词
Immune Tolerance; T-Lymphocyte Subsets; T-Lymphocytes; Regulatory; T淋巴细胞亚群;

机译：Immune Tolerance;T-Lymphocyte Subsets;T-Lymphocytes;Regulatory;T淋巴细胞亚群;

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1. Antigen-specific regulatory T-cell subsets in transplantation tolerance regulatory T-cell subset quality reduces the need for quantity. [J] . Koenen HJ, Joosten I Human Immunology: Official Journal of the American Society for Histocompatibility and Immunogenetics . 2006,第9期

机译：移植耐受性调节性T细胞亚群质量中的抗原特异性调节性T细胞亚群减少了数量需求。
2. In human alloreactive CD4(+) T-cells, dichloroacetate inhibits aerobic glycolysis, induces apoptosis and favors differentiation towards the regulatory T-cell subset instead of effector T-cell subsets [J] . Eleftheriadis Theodoros, Sounidaki Maria, Pissas Georgios, Molecular medicine reports . 2016,第4aPta1期

机译：在人体含有CD4（+）T细胞中，二氯乙酸酯抑制有氧糖溶解，诱导细胞凋亡，并有利于调节T细胞子集的分化，而不是效应T细胞子集
3. Regulatory T-cell subsets and their roles in transplantation tolerance [J] . Wenhao Chen, Li Zhang Current opinion in organ transplantation . 2006,第4期

机译：调节性T细胞亚群及其在移植耐受中的作用
4. Analysis of Cytotoxic T-Cell Subsets in Three Groups of HIV-1+ Patients with Different Response To Highly Active Antiretroviral Therapy (HAART) [C] . S. Magaev, M. Nikolova, A. Michova International AIDS Conference . 2004

机译：三组HIV-1 +患者细胞毒性T细胞亚群分析对高活性抗逆转录病毒治疗（HAART）的不同反应
5. Role of Regulatory T-Cells in Tendon Regeneration [D] . Arvind, Varun. 2021

机译：调节性T细胞在肌腱再生中的作用
6. HIV and Tuberculosis co-infection impacts T-cell activation markers but not the numbers subset of regulatory T-cells in HIV-1 infected patients [O] . Moustapha Mbow, Ndèye S.S. Santos, Makhtar Camara, 2013

机译：HIV和结核病合并感染影响HIV-1感染患者的T细胞活化标志物但不影响调节性T细胞的数目子集
7. HIV and Tuberculosis co-infection impacts T-cell activation markers but not the numbers subset of regulatory T-cells in HIV-1 infected patients [O] . Moustapha Mbow, Ndèye S.S. Santos, Makhtar Camara, 2013

机译：HIV和结核病共感染影响T细胞活化标志物，但不影响HIV-1感染患者中调节性T细胞的数量子集

Antigen-specific regulatory T-cell subsets in transplantation tolerance regulatory T-cell subset quality reduces the need for quantity.

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