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首页> 外文期刊>Human movement science >Handwriting in patients with Parkinson disease: effect of L-dopa and stimulation of the sub-thalamic nucleus on motor anticipation.
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Handwriting in patients with Parkinson disease: effect of L-dopa and stimulation of the sub-thalamic nucleus on motor anticipation.

机译：帕金森病患者的笔迹：左旋多巴和丘脑下核的刺激对运动预期的影响。

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The present research focused on how patients with Parkinson's disease (PD) produce handwriting sequences. PD patients who were on/off medication or deep brain stimulation treatments had to write lll and lln trigrams. We evaluated their ability to anticipate on-line the last letter in the trigram. The results revealed that in PD patients, contrary to healthy participants, the percentage of time taken by the down-stroke of the second l did not vary as a function of the spatial constraints of the following letter (l or n). In other words, the handwriting of the PD patients did not exhibit any sign of motor anticipation. However, under treatment, PD patients exhibited similar results to healthy participants despite no improvement in movement variability. Taken together these results do not seem consistent with the hypothesis that PD patients do not anticipate future movements because of their movement variability. They are more in agreement with theories that postulate that PD patients have a general deficit in the parallel processing of the components of a motor sequence.
机译：本研究的重点是帕金森病（PD）患者如何产生手写序列。接受开/关药物或深部脑刺激治疗的PD患者必须写lll和lln三联词。我们评估了他们在线预测Trigram中最后一个字母的能力。结果显示，在PD患者中，与健康参与者相反，第二次l的下降冲程所花费的时间百分比未随下一个字母（l或n）的空间限制而变化。换句话说，PD患者的笔迹没有表现出任何运动预期的迹象。然而，在治疗下，尽管运动变异性没有改善，PD患者仍显示出与健康受试者相似的结果。综上所述，这些结果似乎与PD患者由于其运动可变性而无法预测未来运动的假设不一致。他们与理论相一致，这些理论认为PD患者在并行处理运动序列的各个成分方面普遍存在缺陷。

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