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DRD4 gene variant associated with body mass: the National Longitudinal Study of Adolescent Health.

机译:与体重相关的DRD4基因变异:青少年健康国家纵向研究。

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摘要

In this article we report a novel statistically significant association between the D4.7/D4.7 genotype of the DRD4 gene and the body mass of black and Hispanic participants in the National Longitudinal Study of Adolescent Health (Add Health). We investigated the role of the 48-bp repeat polymorphism of the dopamine receptor 4 gene (DRD4) in body mass regulation in 2,277 adolescents and young adults followed in 1995 (12-18 years old), 1996, and 2002 by Add Health. After the effects of age, sex, and ethnicity were adjusted, the D4.7/D4.7 genotype reduced the body mass index (BMI)-percentile score by 15 and 12.5, as compared to those with other genotypes, for African-Americans (P = 0.0047) and Hispanic-Americans (P = 0.037), respectively. Although the D4.7/D4.7 genotype was associated with a lower BMI-percentile score in white individuals compared to other genotypes, the difference was not significant. Individuals heterozygous for D4.7 did not differ from those with the other/other genotype.
机译:在本文中,我们报告了国家青少年健康纵向研究(增加健康)中DRD4基因的D4.7 / D4.7基因型与黑人和西班牙裔参与者的体重之间的新型统计学显着关联。我们调查了多巴胺受体4基因(DRD4)48 bp重复多态性在2,277名青少年中的体重调节中的作用,随后在1995年(12-18岁),1996年和2002年由Add Health进行了研究。调整了年龄,性别和种族的影响后,与其他基因型的人相比,D4.7 / D4.7基因型的人体重指数(BMI)-百分位数得分降低了15和12.5 (P = 0.0047)和西班牙裔美国人(P = 0.037)。尽管与其他基因型相比,白人个体的D4.7 / D4.7基因型与较低的BMI百分数相关,但差异并不显着。 D4.7杂合的个体与其他/其他基因型的个体无差异。

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