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首页> 外文期刊>Human vaccines >'runcated abrin A chain expressed in Escherichia coli: A promising vaccine candidate
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'runcated abrin A chain expressed in Escherichia coli: A promising vaccine candidate

机译：“在大肠杆菌中表达的有条理的Abrin A链：有希望的候选疫苗

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摘要

Abrin toxin (AT) is an extremely toxic plant protein derived from the seeds of the plant Abrus precatorius, which originates in Southeast Asia, and is now found in subtropical areas. AT consists of two subunits: an enzymatic A-chain (ATA) and a lectin-active B-chain (ATB). The ATA is a glycosidase that removes an adenine residue from an exposed loop of 28S rRNA, which inhibits protein synthesis to exert its toxic effect. The ATB is the portion that binds (3-D-galactopyranoside moieties on the eukaryotic cell membrane, allowing the ATA enter into the cell.1 Due to its availability, potential lethality, and lack of specific post-exposure treatment, the development of an effective vaccine may be a feasible means of countering the potential biothreat for at-risk populations, such as military populations and research scientists working with abrin.
机译：Abrin毒素（AT）是一种毒性极强的植物蛋白，来源于植物Abrus precatorius的种子，该种子起源于东南亚，现在在亚热带地区发现。 AT由两个亚基组成：酶促A链（ATA）和凝集素活性B链（ATB）。 ATA是一种糖苷酶，可从28S rRNA的裸露环中去除腺嘌呤残基，从而抑制蛋白质合成以发挥其毒性作用。 ATB是在真核细胞膜上结合的部分（3-D-吡喃半乳糖苷部分，允许ATA进入细胞。1）由于其可用性，潜在的致死性和缺乏特异性的暴露后处理，因此，有效的疫苗可能是应对潜在危险威胁的可行方法，这些危险人群包括军事人群和与abrin合作的科研人员。

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