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首页> 外文期刊>Human vaccines >Intranasal immunization with influenza antigens conjugated with cholera toxin subunit B stimulates broad spectrum immunity against influenza viruses
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Intranasal immunization with influenza antigens conjugated with cholera toxin subunit B stimulates broad spectrum immunity against influenza viruses

机译：结合霍乱毒素亚基B的流感抗原进行鼻内免疫可刺激针对流感病毒的广谱免疫

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摘要

Frequent mutation of influenza viruses keep vaccinated and non-vaccinated populations vulnerable to new infections, causing serious burdens to public health and the economy. Vaccination with universal influenza vaccines would be the best way to effectively protect people from infection caused by mismatched or unforeseen influenza viruses. Presently, there is no FDA approved universal influenza vaccine. In this study, we expressed and purified a fusion protein comprising of influenza matrix 2 protein ectodomain peptides, a centralized influenza hemagglutinin stem region, and cholera toxin subunit B. Vaccination of BALB/c mice with this novel artificial antigen resulted in potent humoral immune responses, including induction of specific IgA and IgG, and broad protection against infection by multiple influenza viruses.-Furthermore, our results demonstrated that when used as a mucosal antigen, cholera toxin subunit B improved antigen-stimulated Tcell and memory B cell responses.
机译：流感病毒的频繁突变使接种疫苗的人群和未接种疫苗的人群容易受到新的感染，给公共卫生和经济造成沉重负担。接种通用流感疫苗将是有效保护人们免受因错配或无法预见的流感病毒引起的感染的最佳方法。目前，尚无FDA批准的通用流感疫苗。在这项研究中，我们表达并纯化了一种融合蛋白，该融合蛋白由流感基质2蛋白胞外域肽，集中的流感血凝素干区和霍乱毒素亚基B组成。用这种新型人工抗原对BALB / c小鼠进行疫苗接种可产生有效的体液免疫应答，包括特异性IgA和IgG的诱导，以及针对多种流感病毒感染的广泛保护。此外，我们的结果表明，霍乱毒素B亚单位用作粘膜抗原时，可改善抗原刺激的T细胞和记忆B细胞反应。

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