A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59~R-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration

Giovanni Delia Cioppa; Uwe Nicolay; Kelly Lindert

首页> 外文期刊>Human vaccines >A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59~R-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration

【24h】

A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59~R-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration

机译：一项针对老年人的剂量范围研究，比较了皮内和肌肉内注射MF59〜R佐剂和非佐剂的季节性流感疫苗的安全性和免疫原性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Influenza is a highly contagious disease, which is associated with substantial morbidity and mortality, especially among vulnerable populations such as the elderly.1'2 Preventative, annual vaccination continues to be the most effective strategy to control influenza, and is recommended for all individuals aged 65 y and above.3 However, the clinical efficacy of conventional influenza vaccines decreases with advancing age, and drops from 70-90% in young adults to 17-53% in adults over 65 y of age.4 This reduced immune response in older adults is mainly due to immunosenescence, i.e., an age-related decline in innate and adaptive immune function.5'6 To compensate for the effects of immunosenescence, strategies to enhance the immunogenicity and consequent clinical efficacy of influenza vaccines in older adults are needed to alleviate the burden of influenza-related disease in this rapidly increasing section of the population.

机译：流感是一种高度传染性疾病，与高发病率和高死亡率相关，尤其是在老年人等弱势人群中。1'2预防性年度疫苗接种仍然是控制流感的最有效策略，建议所有年龄段的人都可以使用65岁及以上。3但是，常规流感疫苗的临床疗效随年龄的增长而降低，从年轻人中的70-90％降至65岁以上的成年人中的17-53％。4这降低了老年人的免疫反应成人的主要原因是免疫衰老，即与年龄相关的先天和适应性免疫功能下降。5'6为了补偿免疫衰老的影响，需要采取策略提高老年人的流感疫苗的免疫原性和相应的临床疗效，以期减轻了这一迅速增加的人口中与流感有关的疾病的负担。

著录项

来源
《Human vaccines》 |2014年第6期|共10页
作者
Giovanni Delia Cioppa; Uwe Nicolay; Kelly Lindert;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59~R-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [J] . Giovanni Delia Cioppa, Uwe Nicolay, Kelly Lindert Human vaccines . 2014,第6期

机译：一项针对老年人的剂量范围研究，比较了皮内和肌肉内注射MF59〜R佐剂和非佐剂的季节性流感疫苗的安全性和免疫原性
2. A dose-ranging study of MF59~R-adjuvanted and non-adjuvanted A/H1N1 pandemic influenza vaccine in young to middle-aged and older adult populations to assess safety, immunogenicity, and antibody persistence one year after vaccination [J] . Keith S Reisinger, Sra J Holmes, Paola Pedotti, Human vaccines . 2014,第8期

机译：在年轻人至中年和老年人群中进行MF59〜R佐剂和非佐剂的A / H1N1大流行性流感疫苗的剂量范围研究，以评估接种疫苗后一年的安全性，免疫原性和抗体持久性
3. A dose-ranging study of MF59 (R)-adjuvanted and non-adjuvanted A/H1N1 pandemic influenza vaccine in young to middle-aged and older adult populations to assess safety, immunogenicity, and antibody persistence one year after vaccination [J] . Reisinger Keith S., Holmes Sandra J., Pedotti Paola, Human vaccines & immunotherapeutics. . 2014,第8期

机译：在年轻人到中年和老年人群中进行MF59（R）辅助和非辅助A / H1N1大流行性流感疫苗的剂量范围研究，以评估接种疫苗后一年的安全性，免疫原性和抗体持久性
4. PRE-CLINICAL AND CLINICAL INVESTIGATION OF THE SAFETY AND IMMUNOGENICITY OF A NOVEL INTRANASAL INFLUENZA VACCINE [C] . R. Glueck International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：新型鼻内流感疫苗的安全性和免疫原性的临床前和临床调查
5. The Administration of Intranasal Live Attenuated Influenza Vaccine Induces Changes in the Nasal Microbiota and Nasal Epithelium Gene Expression Profile. [D] . Tarabichi, Yasir. 2015

机译：鼻内减毒活疫苗的使用诱导鼻微生物群和鼻上皮基因表达谱的变化。
6. A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [O] . Giovanni Della Cioppa, Uwe Nicolay, Kelly Lindert, 2014

机译：一项针对老年人的剂量范围研究比较了在皮内和肌肉内施用MF59®佐剂和非佐剂的季节性流感疫苗的安全性和免疫原性
7. A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [O] . Della Cioppa Giovanni, Nicolay Uwe, Lindert Kelly, 2014

机译：一项针对老年人的剂量范围研究，比较皮内和肌内给药后mF59®-佐剂和非佐剂季节性流感疫苗的安全性和免疫原性特征

A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59~R-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration

摘要

著录项

相似文献

相关主题

期刊订阅