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首页> 外文期刊>Human vaccines >Nine mug intradermal influenza vaccine and 15 mug intramuscular influenza vaccine induce similar cellular and humoral immune responses in adults
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Nine mug intradermal influenza vaccine and 15 mug intramuscular influenza vaccine induce similar cellular and humoral immune responses in adults

机译：九杯大头皮内流感疫苗和十五杯大头肌内流感疫苗在成人中诱导相似的细胞和体液免疫反应

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Intramuscular (IM) vaccination with trivalent influenza vaccines induces significant protective antibody responses and remains the cornerstone in preventing seasonal influenza.1 However, due to a variety of reasons, such as not feeling at risk of contracting influenza and fear of needles, seasonal influenza vaccination remains underused, especially in adults.1' Intradermal (ID) injection is an alternative route for delivering seasonal influenza vaccines that also induces a strong protective immune response. ID immunization takes advantage of the high concentration of resident dendritic cells in the skin as well as the extensive vascular and lymphatic network in the dermis, which facilitates recruitment of blood-derived dendritic cells and migration of antigen-presenting cells to the lymph nodes.
机译：肌肉注射三价流感疫苗会诱导显着的保护性抗体反应，并且仍是预防季节性流感的基石。1但是，由于各种原因，例如不感到感染流感的风险和担心扎针，季节性流感疫苗接种仍未得到充分利用，尤其是在成年人中。1'皮内注射是提供季节性流感疫苗的另一种途径，该疫苗还可诱导强烈的保护性免疫反应。 ID免疫利用了皮肤中高浓度的树突状细胞以及真皮中广泛的血管和淋巴网络，从而促进了血液来源的树突状细胞的募集以及抗原呈递细胞向淋巴结的迁移。

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