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首页> 外文期刊>Human vaccines >Methionine enkephalin (MENK) improves lymphocyte subpopulations in human peripheral blood of 50 cancer patients by inhibiting regulatory T cells (Tregs)
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Methionine enkephalin (MENK) improves lymphocyte subpopulations in human peripheral blood of 50 cancer patients by inhibiting regulatory T cells (Tregs)

机译：甲硫氨酸脑啡肽（MENK）通过抑制调节性T细胞（Tregs）改善50位癌症患者外周血中的淋巴细胞亚群

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There are increasing articles supporting that endogenous opioid peptides would be involved in the regulatory loop between the neuroendocrine and immune systems, and play a positive role in immune modulation. Several types of opioid receptors such as: mu, delta, and kappa receptors have been detected on the surface of various immune cells including T cells, NK cells, macrophages, and dendritic cells.1 MENK, composed of Tye-Gly-Gly-Phe-Met, is derived from pre-enkephalin and circulates in blood at low concentration in body.2 The data from both early documented studies3"5 and published results in our laboratory indicated that MENK at suitable range of concentrations could enhance activity of various types of immune cells, like: augmenting interactions between dendritic cells (DCs) and CD4+T cells, induction of phenotypic and functional maturation of DCs with increased antigen presentation, improvement of antitumor activity of DCs loaded with antigen, induction of macrophage polarization to the Ml phenotype in mouse model, eliciting CD8+T cell cytotoxicity, upregulating the secretion of cytokines such as IL-2, IL-12, IFN-7, TNF-alpha, increasing the release of hydrogen peroxide and nitric oxide and stimulation of lymphocyte subpopulations in normal human donors. In addition, there have been studies indicating that MENK could inhibit tumor growth.
机译：越来越多的文章支持内源性阿片肽将参与神经内分泌和免疫系统之间的调节环，并在免疫调节中发挥积极作用。在各种免疫细胞（包括T细胞，NK细胞，巨噬细胞和树突状细胞）的表面上已检测到多种类型的阿片受体，例如：mu，delta和kappa受体。1MENK，由Tye-Gly-Gly-Phe组成-Met来源于脑啡肽前体，在体内低浓度时在血液中循环。2早期文献研究[3] [5]的数据以及我们实验室中发表的结果均表明，在适当浓度范围内的MENK可以增强各种类型免疫细胞，例如：增强树突状细胞（DC）与CD4 + T细胞之间的相互作用，诱导DC的表型和功能成熟，并增加抗原呈递，改善负载抗原的DC的抗肿瘤活性，诱导巨噬细胞极化至M1型在小鼠模型中，引起CD8 + T细胞毒性，上调IL-2，IL-12，IFN-7，TNF-α等细胞因子的分泌，增加过氧化氢和一氧化氮的释放e和刺激正常人供体中的淋巴细胞亚群。另外，有研究表明MENK可以抑制肿瘤的生长。

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