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首页> 外文期刊>Hypertension: An Official Journal of the American Heart Association >Skeletal muscle signaling and the heart rate and blood pressure response to exercise: Insight from heart rate pacing during exercise with a trained and a deconditioned muscle group
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Skeletal muscle signaling and the heart rate and blood pressure response to exercise: Insight from heart rate pacing during exercise with a trained and a deconditioned muscle group

机译：骨骼肌信号传导以及运动对心率和血压的反应：训练有素且肌肉发达的肌肉群从运动过程中的心律起搏中获得洞察力

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摘要

Endurance training lowers heart rate and blood pressure responses to exercise, but the mechanisms and consequences remain unclear. To determine the role of skeletal muscle for the cardioventilatory response to exercise, 8 healthy young men were studied before and after 5 weeks of 1-legged knee-extensor training and 2 weeks of deconditioning of the other leg (leg cast). Hemodynamics and muscle interstitial nucleotides were determined during exercise with the (1) deconditioned leg, (2) trained leg, and (3) trained leg with atrial pacing to the heart rate obtained with the deconditioned leg. Heart rate was ≈15 bpm lower during exercise with the trained leg (P0.05), but stroke volume was higher (P0.05) and cardiac output was similar. Arterial and central venous pressures, rate-pressure product, and ventilation were lower during exercise with the trained leg (P0.05), whereas pulmonary capillary wedge pressure was similar. When heart rate was controlled by atrial pacing, stroke volume decreased (P0.05), but cardiac output, peripheral blood flow, arterial pressures, and pulmonary capillary wedge pressure remained unchanged. Circulating [norepinephrine], [lactate] and [K] were lower and interstitial [ATP] and pH were higher in the trained leg (P0.05). The lower cardioventilatory response to exercise with the trained leg is partly coupled to a reduced signaling from skeletal muscle likely mediated by K, lactate, or pH, whereas the lower cardiac afterload increases stroke volume. These results demonstrate that skeletal muscle training reduces the cardioventilatory response to exercise without compromising O2 delivery, and it can therefore be used to reduce the load on the heart during physical activity.
机译：耐力训练可降低心率和血压对运动的反应，但其机制和后果尚不清楚。为了确定骨骼肌对运动的心脏换气反应的作用，研究了8名健康的年轻男子，在进行1腿膝盖伸肌训练5周和对另一条腿进行2周脱腿训练之前（腿石膏），对这8名健康的年轻人进行了研究。在运动过程中，用（1）脱下腿的腿，（2）训练过的腿和（3）训练过的腿以心律起搏的心律确定血流动力学和肌肉间隙核苷酸。在训练有素的腿部运动期间，心率降低约≈15 bpm（P <0.05），但中风量更高（P <0.05），心输出量相似。在训练有素的腿部锻炼期间，动脉和中央静脉压力，比率压力乘积和通气较低（P <0.05），而肺毛细血管楔压相似。当通过心房起搏控制心律时，中风量减少（P <0.05），但心输出量，外周血流量，动脉压和肺毛细血管楔压保持不变。训练后的腿中循环中的[去甲肾上腺素]，[乳酸]和[K]较低，间质[ATP]和pH较高（P <0.05）。训练有素的小腿对运动的较低的心脏换气反应部分与可能由K，乳酸盐或pH介导的骨骼肌信号转导降低有关，而较低的心脏后负荷会增加中风量。这些结果表明，骨骼肌训练可在不损害O2输送的情况下减少对运动的心脏换气反应，因此可用于减少体育锻炼中心脏的负荷。

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