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首页> 外文期刊>Hypertension: An Official Journal of the American Heart Association >Elevated blood pressure in adolescent boys predicts endothelial dysfunction: the cardiovascular risk in young Finns study.
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Elevated blood pressure in adolescent boys predicts endothelial dysfunction: the cardiovascular risk in young Finns study.

机译：青春期男孩血压升高预示着内皮功能障碍：年轻芬兰人的心血管风险研究。

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Hypertension is a major risk factor for atherosclerosis. It may cause or be a consequence of endothelial dysfunction. We studied whether systolic blood pressure measured in childhood and adolescence predicts endothelial-dependent brachial flow-mediated dilation (FMD) in adulthood. Brachial FMD was measured in 2109 white adults, aged 24 to 39 years, in the 21-year follow-up of the Cardiovascular Risk in Young Finns Study. These subjects have risk factor data available dating back to their childhood (baseline in 1980, ages 3 to 18 years). In male subjects, the level of systolic blood pressure measured in adolescence (at ages 12 to 18 years at baseline) was inversely related to adulthood FMD (P=0.004). This association was independent of brachial diameter and other childhood (P=0.003) and adulthood risk factors, including blood pressure (P=0.03). Childhood (age 3 to 9 years at baseline) systolic blood pressure did not correlate with adult FMD in men or in women (P always >0.2). In male subjects, elevated systolic blood pressure in adolescence predicts impaired brachial endothelial function 21 years later in adulthood. This association is independent of other childhood and adulthood cardiovascular risk factors suggesting that blood pressure elevation in adolescence may have an influence on biological processes that regulate endothelium-dependent flow-mediated vasodilatation capacity.
机译：高血压是动脉粥样硬化的主要危险因素。它可能导致或引起内皮功能障碍。我们研究了在儿童期和青春期测得的收缩压是否可以预测成年期内皮依赖性肱动脉介导的扩张（FMD）。在年轻芬兰人心血管风险研究的21年随访中，对2109名24至39岁的白人成年人进行了肱FMD的测量。这些受试者的危险因素数据可以追溯到他们的童年时期（1980年为基线，年龄为3至18岁）。在男性受试者中，青春期（基线时为12至18岁）测得的收缩压水平与成年FMD成反比（P = 0.004）。这种关联与肱动脉直径和其他儿童时期（P = 0.003）以及成年危险因素，包括血压（P = 0.03）无关。儿童期（基线年龄为3至9岁）的收缩压与男性或女性的成年FMD无关（P始终> 0.2）。在男性受试者中，青春期收缩压升高预示成年后21年肱动脉内皮功能受损。这种关联独立于其他儿童和成年期的心血管危险因素，提示青春期血压升高可能会对调节内皮依赖性血流介导的血管舒张能力的生物过程产生影响。

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