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首页> 外文期刊>Human Pathology >Diagnostic utility of MYC amplification and anti-MYC immunohistochemistry in atypical vascular lesions, primary or radiation-induced mammary angiosarcomas, and primary angiosarcomas of other sites.
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Diagnostic utility of MYC amplification and anti-MYC immunohistochemistry in atypical vascular lesions, primary or radiation-induced mammary angiosarcomas, and primary angiosarcomas of other sites.

机译：MYC扩增和抗MYC免疫组化在非典型血管病变，原发性或放射性乳腺血管肉瘤以及其他部位的原发性血管肉瘤中的诊断作用。

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摘要

Breast cancer patients who receive radiation therapy or develop chronic lymphedema following axillary dissection can develop secondary mammary angiosarcomas (ASs) and, additionally, atypical vascular lesions (AVLs) in the former group. Recently, MYC amplification by fluorescence in situ hybridization (FISH) has been identified in secondary mammary AS but not in AVL and most primary mammary AS as well as AS of other sites. We studied MYC amplification and MYC protein expression in 7 radiation-induced AVLs, 9 secondary mammary ASs, 17 primary mammary ASs, and 20 primary ASs of other sites by FISH analysis and immunohistochemistry. All 9 secondary mammary ASs showed gene amplification and protein expression, whereas neither was found in any of 7 AVLs. No MYC amplification or protein expression was identified in any of the 17 primary mammary ASs. Among primary ASs of other sites, 1 cardiac AS and 1 skin AS showed gene amplification and protein expression. The remaining 18 did not show amplification (90%), but some demonstrated protein expression (39%). We conclude that MYC amplification by FISH is present in secondary mammary AS but not in AVL. We also found MYC amplification in 1 primary skin AS and 1 primary cardiac AS. There was 100% concordance between MYC amplification and protein expression in all AVL, primary mammary AS, and secondary mammary AS, whereas only 65% concordance was found in AS of other sites. MYC protein expression in AS can be helpful in certain diagnostic scenarios in the breast but not in other sites.
机译：接受放射治疗或腋窝淋巴结肿大后出现慢性淋巴水肿的乳腺癌患者可能会发展为继发性乳腺血管肉瘤（ASs），此外，在前一组中还会出现非典型血管病变（AVL）。最近，在继发性乳腺AS中发现了通过荧光原位杂交（FISH）进行的MYC扩增，但在AVL和大多数原发性乳腺AS以及其他位点的AS中并未发现。我们通过FISH分析和免疫组织化学研究了7个辐射诱导的AVL，9个继发性乳腺AS，17个原发性乳腺AS和其他部位的20个原发性AS的MYC扩增和MYC蛋白表达。所有9个次级乳腺AS均显示基因扩增和蛋白表达，而在7个AVL中均未发现。在这17种原发性乳腺AS中均未发现MYC扩增或蛋白表达。在其他部位的原发性AS中，有1例心脏AS和1例皮肤AS显示基因扩增和蛋白质表达。其余18个未显示扩增（90％），但一些显示了蛋白表达（39％）。我们得出结论，通过FISH进行MYC扩增存在于继发性乳腺AS中，而不存在于AVL中。我们还发现1例原发性皮肤AS和1例原发性心脏AS的MYC扩增。在所有AVL，原发性乳腺AS和继发性乳腺AS中，MYC扩增与蛋白质表达之间存在100％的一致性，而在其他位点的AS中仅发现65％的一致性。 AS中的MYC蛋白表达在乳腺的某些诊断情况下可能会有所帮助，但在其他部位则没有帮助。

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