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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Combination of ziprasidone and clozapine in treatment-resistant schizophrenia.
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Combination of ziprasidone and clozapine in treatment-resistant schizophrenia.

机译：齐拉西酮和氯氮平联用治疗难治性精神分裂症。

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摘要

In cases of treatment-resistant schizophrenia the combined application of antipsychotic drugs often becomes necessary. Clozapine has been combined successfully with other atypical antipsychotic drugs such as risperidone or amisulpride in the past.We report the difficult treatment of a 28-year-old schizophrenic woman. Psychotic symptoms were found resistant to monotherapy with clozapine or ziprasidone. In contrast, combined application led to a marked improvement in both positive and negative symptoms of schizophrenia along with a decrease of side effects.The reported combination is a promising option in cases of treatment-resistant schizophrenia and should be further evaluated in prospective studies.
机译：在难治性精神分裂症的情况下，抗精神病药的联合应用常常变得必要。过去，氯氮平已成功与其他非典型抗精神病药物如利培酮或氨磺必利合用。我们报道了一名28岁精神分裂症妇女的治疗困难。发现精神病性症状对氯氮平或齐拉西酮的单药治疗有抵抗力。相比之下，联合应用可导致精神分裂症的阳性和阴性症状显着改善以及副作用的减少。据报道，该组合在耐药性精神分裂症患者中是一种有希望的选择，应在前瞻性研究中进行进一步评估。

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