...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Human Reproduction >Evaluating testis function non-invasively: how epidemiologist-andrologist teams might better approach this task.
【24h】

Evaluating testis function non-invasively: how epidemiologist-andrologist teams might better approach this task.

机译：评估睾丸的功能是非侵入性的：流行病学家和男科医师团队如何更好地完成这项任务。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Opinions herein focus on epidemiology-based publications using semen to study testis function, but several have broader applicability. 'Opinion 1': authors often fail to write out an explicit question(s) or hypothesis, and to stipulate how measured outcomes will be used to refute or support the hypothesis. Might critical thinking be lax? 'Opinion 2': authors often fail to consider the biology underlying a question or hypothesis, and/or which analytical methods really provide meaningful information or should be rejected. 'Opinion 3': spermatogenesis cannot be evaluated in a meaningful manner via conventional semen attributes. Quantitative evaluation of spermatogenesis requires a 'rate attribute', not provided by number of sperm per milliliter of semen or total number per ejaculate (TSperm). Influence of abstinence interval is under-appreciated. The rate attribute, TSperm per hour of abstinence (TSperm/h), meaningfully estimates sperm production if the abstinence interval is 42-60 h. Most attributes of individual sperm do not reflect quality at spermiation. 'Opinion 4': reliance on a single semen sample per subject might hamper detection of the association sought, because an imprecise value might not establish if a subject's testes were dysfunctional or not. 'Opinion 5': curve-fitting, to adjust quantitative data, for a sample provided after an abstinence interval falling within a broad range, to a standardized abstinence interval, distorts outcomes for many samples provided after approximately 60 h abstinence. TSperm values for individuals with good daily sperm production are artifactually low and those for individuals with poor daily sperm production are artifactually high. Hence, it is important to explain the importance of abstinence interval to participants and censor samples outside an acceptable 37-64 h abstinence range.
机译：本文的观点集中于使用精液研究睾丸功能的基于流行病学的出版物，但其中一些具有更广泛的适用性。 “意见1”：作者经常没有写出明确的问题或假设，也没有规定如何使用测得的结果来驳斥或支持该假设。批判性思维会放松吗？ “意见2”：作者经常没有考虑问题或假设的生物学基础，和/或哪种分析方法确实提供了有意义的信息，或者应该被拒绝。 “意见3”：无法通过常规精液属性以有意义的方式评估精子发生。精子发生的定量评估需要一个“比率属性”，而不是由每毫升精液的精子数量或每个射精的总数量（TSperm）提供。禁欲间隔的影响被低估了。如果禁欲间隔为42至60小时，则速率属性（每小时禁欲的TSperm（TSperm / h））可有意义地估计精子的产生。单个精子的大多数属性不能反映精子的质量。 “意见4”：每个受试者依赖单个精液样本可能会妨碍所寻求的关联的检测，因为受试者的睾丸功能是否正常可能无法确定不精确的值。 “意见5”：对于禁酒间隔在宽范围内后提供的样品，将曲线拟合拟合以调整定量数据至标准禁酒间隔，会使禁酒60小时后提供的许多样品的结果失真。每天精子产量高的人的TSperm值在人为方面较低，而每天精子产量差的人的TSperm值在人为方面较高。因此，重要的是要说明禁欲间隔对参与者和检查员样本超出可接受的37-64小时禁欲范围的重要性。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号