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首页> 外文期刊>Human and Experimental Toxicology >Altered expressions of MMP-2, MMP-9, and TIMP-2 in placentas from women exposed to lead
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Altered expressions of MMP-2, MMP-9, and TIMP-2 in placentas from women exposed to lead

机译：接触铅的妇女胎盘中MMP-2，MMP-9和TIMP-2的表达改变

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Experimental studies have shown that prenatal exposure to lead (Pb) produces morphological changes related to extracellular matrix remodelling. To analyse whether the matrix metalloproteinases (MMPs), particularly MMP-2, MMP-9, and the tissue inhibitor of metalloproteinases-2 (TIMP-2), are associated with morphological alterations found in placentas, the expression of these enzymes was evaluated by immunohistochemical and image analyses in placentas of women with histories of environmental exposure to Pb. The median maternal concentration of Pb in blood was 4.68 μg/dL (x? = 5.85 ± 6.48 μg/dL). Significant differences related to the exposure to Pb were not detected in newborn or placenta weight. MMP-2, MMP-9, and TIMP-2 were expressed in the syncytiotrophoblast layer of placental villi. A significant increase in both MMP-2 and MMP-9 was observed in placentas of women with concentrations of Pb in blood >4.68 μg/dL (p = 0.01 and 0.03 for MMP-2 and MMP-9, respectively) and decrease in TIMP-2 expression (p = 0.01) resulted in a significant increase in MMP-2/TIMP-2 ratio (p < 0.01). Increased expression of MMPs may be induced to aid in repairing placental tissue damaged by the exposure to Pb and that TIMP-2 decreases its expression to permit tissue repair. Increased expression of MMPs may be important to consider as a mechanism for generating placental abnormalities and in the induction of preterm delivery or abortion.
机译：实验研究表明，产前铅（Pb）暴露会产生与细胞外基质重塑有关的形态变化。为了分析基质金属蛋白酶（MMP），特别是MMP-2，MMP-9和金属蛋白酶2的组织抑制剂（TIMP-2）是否与胎盘中发现的形态学改变有关，通过以下方法评估了这些酶的表达有环境铅暴露史的妇女胎盘的免疫组织化学和图像分析。孕妇血液中Pb的中位数浓度为4.68μg/ dL（x？= 5.85±6.48μg/ dL）。在新生儿或胎盘重量中未发现与铅暴露相关的显着差异。 MMP-2，MMP-9和TIMP-2在胎盘绒毛的合体滋养层中表达。在血液中Pb浓度> 4.68μg/ dL的妇女的胎盘中，MMP-2和MMP-9均显着增加（MMP-2和MMP-9分别为p = 0.01和0.03），TIMP下降-2表达（p = 0.01）导致MMP-2 / TIMP-2比率显着增加（p <0.01）。可以诱导MMPs表达的增加，以帮助修复因暴露于Pb而受损的胎盘组织，TIMP-2降低其表达以进行组织修复。 MMPs表达的增加可能被认为是产生胎盘异常和诱导早产或流产的重要机制。

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