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Vestibular effects of lidocaine intratympanic injection in rats

机译：利多卡因鼓膜内注射对大鼠的前庭作用

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摘要

When lidocaine is locally delivered into the inner ear, it rapidly paralyzes the peripheral vestibular afferent neurons and induces unilateral vestibular loss. The goals of this study were to explore the possibility of developing intratympanic injection (IT) of lidocaine as a modality for treating acute vertigo. To evaluate the minimum concentration required, latent time, action duration, and possibility of lidocaine IT readministration to the vestibular system, we compared the development of horizontal nystagmus after IT of 2, 4, 6, 8, and 10% lidocaine solutions in rats. To identify the induction of vestibular compensation, c-Fos-like protein expression was observed in the vestibular nucleus. Results of our investigation showed that lidocaine IT concentrations greater than 4% induced vestibular hyporeflexia in the injected ear. In order to induce hyporeflexia 4 and 6% lidocaine solutions could also be repeatedly injected. Regardless of concentration, effects of the lidocaine IT dissipated gradually over time. Our findings could be used to develop novel methods for symptom control in vestibular disorder patients.
机译：当利多卡因局部递送到内耳中时，它迅速使周围前庭传入神经元麻痹，并引起单侧前庭损失。这项研究的目的是探讨开发鼓膜内注射利多卡因治疗急性眩晕的可能性。为了评估所需的最低浓度，潜伏时间，动作持续时间以及利多卡因IT再给药至前庭系统的可能性，我们比较了IT，2％，4％，6％，8％和10％利多卡因溶液后水平眼球震颤的发展。为了确定诱导前庭补偿，在前庭核中观察到c-Fos样蛋白表达。我们的研究结果表明，利多卡因IT浓度大于4％会引起注射耳朵的前庭反射不足。为了引起反射不足，还可以反复注射4％和6％的利多卡因溶液。无论浓度如何，利多卡因IT的作用会随着时间逐渐消散。我们的发现可用于开发前庭疾病患者症状控制的新方法。

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