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Implications of hormesis for industrial hygiene.

机译:兴奋剂对工业卫生的影响。

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This paper considers hormesis as a valid and potentially valuable alternative hypothesis for low-dose response in the context of occupational health risk assessment. It outlines the current occupational risk assessment paradigm and its use of high-dose toxicological data in setting occupational exposure limits (OELs). This present effort is a call to science to investigate the potential promise of hormesis in providing prima facie experimental evidence for a low-dose threshold of toxic effect to chemical agents. The scientific effort and advancement advised in this piece could also lead to experimentally validated quantitative estimates of the toxic effect extant at occupational exposures in the region of the OEL.
机译:本文认为在职业健康风险评估的背景下,兴奋剂是低剂量反应的有效且可能有价值的替代假设。它概述了当前的职业风险评估范式及其在设定职业接触限值(OELs)中使用大剂量毒理学数据的方法。目前的努力是呼吁科学界调查在提供低剂量阈值对化学试剂产生毒性的初步实验证据方面,兴奋剂的潜在前景。本文建议的科学努力和进步也可能导致对实验性验证的OEL区域职业暴露时存在的毒性作用进行定量估计。

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