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首页> 外文期刊>Human and Experimental Toxicology >Comments: implications of hormesis for industrial hygienists.
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Comments: implications of hormesis for industrial hygienists.

机译：评论：兴奋剂对工业卫生学家的影响。

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Quantitative health risk assessment is based on extrapolating from the high-dose end of the dose-response curve to points close to the origin or the threshold where the dose levels are closer to the lower environmental or occupational exposures. Hormesis is demonstrated in chronic toxicological studies where the animals treated at the lowest experimental dose appear to be healthier than the controls, as evidenced by longer life spans, less disease and/or increased body weight. If the occupational exposure limit (OEL) or environmental exposure limit (EEL) is in the range of the hormetic effect, or lower than the hormetic effect, then a case could be made that exposure at the OEL or EEL is 'safe.' This idea is controversial because it challenges some of the basic assumptions of quantitative health risk assessment as it has been practiced during the past 50 years. De-emphasis of the dose-response curve in determining OELs and EELs will occur not because of hormesis, but because the emerging sciences of genomics and proteomics will shift the focus from statistical methods to individuals as genetic and protein engineering becomes more sophisticated and powerful.
机译：定量健康风险评估基于从剂量反应曲线的高剂量端向接近起始点或阈值（其中剂量水平更接近较低环境或职业暴露）的点进行推断。在慢性毒理学研究中证明了兴奋作用，其中以最低实验剂量治疗的动物似乎比对照组更健康，这可以通过更长的寿命，更少的疾病和/或体重增加来证明。如果职业暴露极限（OEL）或环境暴露极限（EEL）在致敏效应范围内，或低于致敏效应，则可能会出现在OEL或EEL处暴露是“安全”的情况。这个想法是有争议的，因为它挑战了过去50年中实践的量化健康风险评估的一些基本假设。在确定OELs和EELs时，剂量-反应曲线不再强调，不是因为兴奋剂，而是因为随着基因组和蛋白质工程变得更加复杂和强大，新兴的基因组学和蛋白质组学将把重点从统计方法转移到个人身上。

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