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Acid-base conditions regulate calcium and magnesium homeostasis.

机译:酸碱条件调节钙和镁的稳态。

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摘要

Background. Previous experimental studies demonstrate that the acid-base balance influences mineral homeostasis by regulating the absorption of calcium and magnesium in the kidneys. No intervention studies are available on population samples. Aims. To study the urinary excretion of calcium and magnesium before and after an intervention with the aim of decreasing the acid load. Methods. Healthy subjects aged 50-75 years were recruited by advertising. Urinary calcium, magnesium and urea as well as blood pressure were measured before and after the intervention. This comprised taking tablets containing potassium hydrogen carbonate or potassium chloride (placebo) during 7-10 days. Results. There were significant relationships between the urinary excretion of urea and magnesium and calcium before the intervention. Comparing before and after intervention, the change in urinary excretion of urea was related to a change in urinary excretion of calcium and magnesium. There was a significant decrease in systolic as well as diastolic blood pressure both after administration of potassium hydrogen carbonate and citrate. Conclusion. The results confirm previous studies showing a relation between acid conditions in the body and the excretion of calcium and add new data on magnesium. A blood pressure decrease after potassium has been found in previous studies. This suggests an alternative for the treatment of moderately increased levels of blood pressure that should be further explored.
机译:背景。先前的实验研究表明,酸碱平衡通过调节肾脏中钙和镁的吸收来影响矿物质的体内稳态。没有针对人群样本的干预研究。目的为了减少酸负荷,研究干预前后钙和镁的尿排泄。方法。通过广告招募50-75岁的健康受试者。干预前后测量尿钙,镁,尿素以及血压。这包括在7-10天内服用含碳酸氢钾或氯化钾(安慰剂)的片剂。结果。干预前尿中尿液排泄与镁和钙之间存在显着关系。比较干预前后尿素尿排泄的变化与钙,镁尿排泄的变化有关。碳酸氢钾和柠檬酸钾给药后,收缩压和舒张压均显着降低。结论。结果证实了先前的研究,这些研究表明了体内酸性条件与钙排泄之间的关系,并增加了镁的新数据。在先前的研究中,发现钾后血压降低。这表明治疗中度升高的血压的替代方法应进一步探索。

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