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首页> 外文期刊>Zeitschrift fur Gastroenterologie >Personalised hepatology - Current concepts, developments and expectations in the post-genome era [Personalisierte Hepatologie - Gegenw?rtige Konzepte, Entwicklungen und Erwartungen im Postgenomzeitalter]
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Personalised hepatology - Current concepts, developments and expectations in the post-genome era [Personalisierte Hepatologie - Gegenw?rtige Konzepte, Entwicklungen und Erwartungen im Postgenomzeitalter]

机译：个性化肝病学-后基因组时代的当前概念，发展和期望[个性化肝病学-后基因组时代的当前概念，发展和期望]

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摘要

Promoted by the decoding of the human genome as part of the human genome project, individualised therapy approaches have become a realistic perspective for therapies that are more effective, less prone to side effects and economically reasonable. This also applies to chronic liver disease. With the aim not only to expand the current knowledge base through basic research on the underlying disease processes and treatment options but also to identify and characterise biomarkers, the creation of genetic fingerprints for individualised diagnosis, prognosis and treatment of patients takes its place in the centre of translational hepatology. For certain liver diseases personalised therapy approaches are already existent. Examples are the determination of viral genotypes, viral kinetics and genotyping of the IL28B polymorphism to optimise the treatment of chronic hepatitis C. The challenges of the next few years relate to the broadening of the knowledge base, the establishment of reliable and standardised technologies, and the development of intelligent bioinformatics strategies for data analysis and data integration. The following review not only summarises the current state of progress and possibilities of personalised medicine in hepatological diseases, but also explains the technical background of the limitations that currently hinder a consistent clinical implementation.
机译：作为人类基因组计划的一部分，通过对人类基因组进行解码的推动，个体化治疗方法已成为更有效，更不易产生副作用且在经济上合理的治疗方法的现实观点。这也适用于慢性肝病。为了不仅通过对潜在疾病过程和治疗方案的基础研究来扩展当前的知识基础，而且还旨在识别和表征生物标志物，将基因指纹图谱的创建用于患者的个性化诊断，预后和治疗，肝病学对于某些肝脏疾病，个性化治疗方法已经存在。例如，确定病毒基因型，病毒动力学和IL28B多态性的基因分型以优化慢性丙型肝炎的治疗。未来几年的挑战涉及知识库的扩大，可靠和标准化技术的建立以及开发用于数据分析和数据集成的智能生物信息学策略。以下评论不仅总结了肝病中个性化医学的最新进展和可能性，而且还解释了目前阻碍一致临床实施的局限性的技术背景。

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