Cytotoxic, DNA interaction, SOD mimic, and antimicrobial activities of square pyramidal copper(II) complexes

Patel M.N.; Patel C.R.; Joshi H.N.

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Cytotoxic, DNA interaction, SOD mimic, and antimicrobial activities of square pyramidal copper(II) complexes

机译：方形金字塔形铜（II）配合物的细胞毒性，DNA相互作用，SOD模拟和抗菌活性

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The copper(II) complexes with NS donor ligand and ciprofloxacin were synthesized. The synthesized complexes were characterized by physicochemical parameters like elemental and thermal analysis, electronic, FT-IR, and LC-MS spectroscopy. The complexes were tested for their antibacterial activity against two Gram(+ve) i.e. Staphylococcus aureus, Bacillus subtilis and three Gram(-ve) i.e., Serratia marcescens, Pseudomonas aeruginosa, Escherichia coli bacteria in terms of MIC (μM) and the results were compared with the parent drug. Viscosity measurement and absorption titration were employed to determine the mode of binding of complexes with DNA. DNA cleavage activity was carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA. The complexes were screened for their SOD mimic activity in terms of IC _(50) value. The complexes were also checked for their cytotoxicity using brine shrimp assay method.

机译：合成了具有NS供体配体和环丙沙星的铜（II）配合物。合成的配合物通过物理化学参数（如元素分析和热分析，电子，FT-IR和LC-MS光谱）进行表征。测试了复合物对两种革兰氏阳性菌（+ ve），即金黄色葡萄球菌，枯草芽孢杆菌和三种革兰氏阴性菌（即粘质沙雷氏菌，铜绿假单胞菌，大肠杆菌）的抗菌活性，以MIC（μM）表示。与母体药物相比。使用粘度测量和吸收滴定来确定复合物与DNA的结合模式。通过超电泳形式的pUC19 DNA的凝胶电泳实验进行DNA切割活性。根据IC_（50）值筛选复合物的SOD模拟活性。还使用盐水虾测定法检查复合物的细胞毒性。

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《Zeitschrift fur Anorganische und Allgemeine Chemie》 |2012年第8期|共9页
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Patel M.N.; Patel C.R.; Joshi H.N.;
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正文语种 eng
中图分类化学;
关键词
Antibacterial activity; Ciprofloxacin; Copper; Cytotoxicity; DNA interaction; NS donor ligand;

机译：抗菌活性;环丙沙星;铜;细胞毒性;DNA相互作用;NS供体配体;

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1. Cytotoxic, DNA interaction, SOD mimic, and antimicrobial activities of square pyramidal copper(II) complexes [J] . Patel M.N., Patel C.R., Joshi H.N. Zeitschrift fur Anorganische und Allgemeine Chemie . 2012,第7a8期

机译：方形金字塔形铜（II）配合物的细胞毒性，DNA相互作用，SOD模拟和抗菌活性
2. Square pyramidal copper(II) complexes with forth generation fluoroquinolone and neutral bidentate ligand: structure, antibacterial, SOD mimic and DNA-interaction studies. [J] . Patel MN, Parmar PA, Gandhi DS Bioorganic and medicinal chemistry . 2010,第3期

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3. Antimalarial, antimicrobial, cytotoxic, DNA interaction and SOD like activities of tetrahedral copper(II) complexes [J] . Mehta Jugal V., Gajera Sanjay B., Patel Mohan N. Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy . 2015,第Pta3期

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4. Chitosan- Copper(II) , Zinc(II) and Ferric(II) Complexes as Antimicrobial Agent: Synthesis, Characterization and Structure- Activity Study [C] . Xiaohui Wang, Yumin Du, Fei Huang Polymeric Materials: Science Engineering Symposia . 2005

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6. Copper(II) Complexes with NO-Donor Ligands and Ofloxacin Drug as Antibacterial DNA Interacting Cytotoxic and SOD Mimic Agent [O] . Parag S. Karia, Pankajkumar A. Vekariya, Anshul P. Patidar, 2015

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7. Metal based pharmacologically active agents: Synthesis, structural elucidation, DNA interaction, in vitro antimicrobial and in vitro cytotoxic screening of copper(II) and zinc(II) complexes derived from amino acid based pyrazolone derivatives [O] . Raman N., Jeyamurugan R., Sudharsan S., 2013

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8. Novel Square Pyramidal Copper(II) Complexes of the Stereospecific Linear NSNNTetradentate Ligand N-((2-Pyridyl)methyl)-2-((2-Aminoethyl)thio) Acetamide (pygeH). The Crystal Structures of (Cu(pyge)X) (X = Br, N3) [R] . Toscano, P. J., Fordon, K. J., Macherone, D., 1990

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Cytotoxic, DNA interaction, SOD mimic, and antimicrobial activities of square pyramidal copper(II) complexes

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