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首页> 外文期刊>Zoonoses and Public Health >Recurrence of human Streptococcus suis infections in 2007: three cases of meningitis and implications that heterogeneous S. suis 2 circulates in China.
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Recurrence of human Streptococcus suis infections in 2007: three cases of meningitis and implications that heterogeneous S. suis 2 circulates in China.

机译:2007年人类猪链球菌感染的复发:3例脑膜炎及其异质性 S的影响。 suis 2在中国发行。

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摘要

Emergence of fatal Streptococcus suis serotype 2 (S. suis 2, SS2) in China, 2005, has greatly challenged the public health, raising serious concerns about its global circulation. Whole genome sequencing of the representative strains has identified a potential pathogenicity island (PAI), named 89K. Here, we reported the recurrence of human S. suis meningitis cases (two in Shenzhen City and one in Sichuan Province) in China, in 2007. Multiple lines of evidence supported that these human cases are caused by highly pathogenic SS2 isolates. Pulsed-field gel electrophoresis analysis indicated that these re-emerging SS2 isolates (07CQH01, 07SZH01 and 07SZH02) can be featured with different genotypes. Molecular dissection demonstrated that they all share 89K, the newly proposed PAI that is common to 2005 prevalent strains in China. Further mapping of 89K revealed that gene losses/deletions occur in 07CQH01 and 07SZH01, except 07SZH02. These findings suggested that heterogeneous SS2 circulates in China, with the capability of causing endemic with life-threatening danger.
机译:2005年在中国出现的致命猪链球菌血清型2(猪链球菌2,SS2)极大地挑战了公众健康,引起了人们对其全球流通的严重关注。代表菌株的全基因组测序已鉴定出一个潜在的致病岛(PAI),名为89K。在这里,我们报道了人类 S的复发。 2007年,中国出现了猪脑膜炎病例(深圳2例,四川省1例)。多方面的证据支持这些人类病例是由高致病性SS2分离株引起的。脉冲场凝胶电泳分析表明,这些重新出现的SS2分离株(07CQH01、07SZH01和07SZH02)可以具有不同的基因型。分子解剖表明,它们都共享89K,这是新提议的PAI,在中国2005年流行的菌株中很常见。 89K的进一步作图表明,基因缺失/缺失发生在07CQH01和07SZH01中,除了07SZH02。这些发现表明,异质性SS2在中国流行,具有引起地方性生命危险的能力。

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