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首页> 外文期刊>Zoological Science >The cooperativity of human fetal and adult hemoglobins is optimized: A consideration based on the effectiveness of the Bohr shift
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The cooperativity of human fetal and adult hemoglobins is optimized: A consideration based on the effectiveness of the Bohr shift

机译：优化了人类胎儿和成人血红蛋白的协同性：基于玻尔移位有效性的考虑

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摘要

The physiological significance of the cooperativity of human hemoglobin (Hb) is considered from the viewpoint of the effectiveness of the Bohr shift at the sites of O-2 release and uptake across the placental membrane. The effects of the Bohr shift was examined by changing the O-2 saturation of Hb (S-(pO2)) per unit change in P-50, -dS((PO2))/dP(50), where P-50 is partial pressure of O-2 at half saturation. The Bohr shift at the sites of O-2 uptake and release was found to be highly effective in both fetal and maternal bloods at physiological degree of cooperativity (Hill's coefficient, n=2.65). From the results obtained in this paper, it is concluded that the positions of OECs of fetal and maternal Hbs are regulated to receive a maximal benefit from the Bohr shift, and that a relatively low n value of human tetrameric Hb is adequate for the O-2 and CO2 exchange across the placental membrane.
机译：从在穿过胎盘膜的O-2释放和摄取部位的玻尔移位的有效性的观点考虑，人类血红蛋白（Hb）协同作用的生理意义。通过更改P-50中每单位变化Hb的O-2饱和度（S-（pO2））来检查玻尔位移的影响，-dS（（PO2））/ dP（50），其中P-50为O-2在半饱和时的分压。发现在生理合作度下，在胎儿和母体血液中，O-2吸收和释放部位的玻尔位移都非常有效（希尔系数，n = 2.65）。根据本文获得的结果，可以得出结论，胎儿和母体Hb的OEC位置受到了调节，可以从Bohr移位中获得最大收益，并且相对较低的人四聚体Hb n值足以满足O- 2和CO2跨胎盘膜交换。

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