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首页> 外文期刊>Zoological Science >5-HT7-like receptors mediate serotonergic modulation of photo-responsiveness of the medulla bilateral neurons in the cricket, Gryllus bimaculatus
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5-HT7-like receptors mediate serotonergic modulation of photo-responsiveness of the medulla bilateral neurons in the cricket, Gryllus bimaculatus

机译：5-HT7样受体介导ser的双侧延髓神经元的光响应性的血清素能调节。

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摘要

Serotonin (5-HT) suppresses the photo-responsiveness of medulla bilateral neurons (MBNs) that are involved in the coupling mechanism of the bilaterally paired optic lobe circadian pacemakers in the cricket, Gryllus bimaculatus. We found that forskolin, a highly specific activator of adenylate cyclase, mimicked the effects of serotonin on the MBNs. This fact suggests the involvement of cyclic 3', 5'-adenosine monophosphate (cAMP) in mediating the action of serotonin. We therefore tested the effects of various 5-HT receptor agonists and antagonists that are coupled to adenylate cyclase to specify the receptor involved. Application of 8-OH-DPAT that has affinity for both 5-HT1A and 5-HT7 receptors suppressed the photo-responsiveness, like forskolin. The inhibitory effect of 8-OH-DPAT was effectively blocked by clozapine, a high affinity 5-HT7 receptor antagonists with a very low affinity for 5-HT2. Ketanserin, a selective 5-HT2 antagonist, and NAN-190, a 5-HT1A antagonist, did not block it. These results suggest that serotonergic suppression of the photo-responsiveness of the MBNs is mediated by 5-HT7-like receptor subtypes.
机译：血清素（5-HT）抑制了of双侧视神经节律起搏器在G Gryllus bimaculatus的耦合机制中所涉及的髓质双侧神经元（MBN）的光反应性。我们发现福斯克林是腺苷酸环化酶的高度特异性激活剂，可模仿5-羟色胺对MBN的作用。这一事实表明环状3'，5'-腺苷单磷酸（cAMP）参与介导5-羟色胺的作用。因此，我们测试了与腺苷酸环化酶偶联以指定参与受体的各种5-HT受体激动剂和拮抗剂的作用。对5-HT1A和5-HT7受体都具有亲和力的8-OH-DPAT的应用抑制了光响应性，如毛喉素。氯氮平是对5-HT2的亲和力极低的高亲和力5-HT7受体拮抗剂氯氮平，可有效阻断8-OH-DPAT的抑制作用。选择性5-HT2拮抗剂Ketanserin和5-HT1A拮抗剂NAN-190没有阻止它。这些结果表明，MBNs的光反应性的5-羟色胺能抑制是由5-HT7样受体亚型介导的。

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