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首页> 外文期刊>Zoological Science >Release of Relaxin-Like Gonad-Stimulating Substance from Starfish Radial Nerves by Ionomycin
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Release of Relaxin-Like Gonad-Stimulating Substance from Starfish Radial Nerves by Ionomycin

机译：碘菌素从海星Rad神经释放类似松弛素的性腺刺激物质

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摘要

In starfish, the peptide hormone gonad-stimulating substance (GSS) secreted from nervous tissue stimulates oocyte maturation to induce 1-methyladenine (1-MeAde) production by ovarian follicle cells. Recently, GSS was purified from radial nerves of the starfish Asterina pectinifera and identified as a relaxin-like peptide. This study examines the mechanism of GSS secretion from radial nerves. When radial nerves isolated from A. pectinifera were incubated in artificial seawater containing ionomycin as a calcium ionophore, GSS release increased in a dose-dependent manner; 50% activity of GSS release was obtained with approximately 10 mu M ionomycin. Another calcium ionophore, A23187, also stimulated GSS release from radial nerves. In contrast, membrane permeable cyclic AMP and cyclic GMP analogs failed to induce GSS release. These results suggest that GSS secretion is induced by intracellular Ca2+ as a second messenger.
机译：在海星中，从神经组织分泌的肽激素性腺刺激物质（GSS）刺激卵母细胞成熟，诱导卵巢卵泡细胞产生1-甲基腺嘌呤（1-MeAde）。最近，从海星果蝇Asterina pectinifera的radial神经中纯化出GSS，并将其鉴定为松弛素样肽。这项研究探讨了radial神经分泌GSS的机制。当将从果胶曲霉分离的radial神经在含有离子霉素作为钙离子载体的人工海水中孵育时，GSS释放以剂量依赖性方式增加;用约10μM的离子霉素获得了50％的GSS释放活性。另一个钙离子载体A23187也刺激了radial神经从from神经释放。相反，膜可渗透的环状AMP和环状GMP类似物未能诱导GSS释放。这些结果表明，细胞内Ca 2+作为第二信使诱导了GSS的分泌。

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