The Gonadotropin Releasing Hormone (GnRH)-like Molecule in Prosobranch Patella caerulea: Potential Biomarker of Endocrine-disrupting Compounds in Marine Environments

De Lisa Emilia; Carella Francesca; De Vico Gionata; Di Cosmo Anna

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The Gonadotropin Releasing Hormone (GnRH)-like Molecule in Prosobranch Patella caerulea: Potential Biomarker of Endocrine-disrupting Compounds in Marine Environments

机译：Prosobranch Pat菜中的促性腺激素释放激素（GnRH）样分子：海洋环境中破坏内分泌的化合物的潜在生物标志物

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It has been reported that endocrine disruptor compounds (EDCs) interfere with the endocrine system, mimicking the action of sex steroid hormones in different species of mollusks. Prosobranchs are frequently used as a reliable bioindicator to evaluate EDC exposure. In this article, we evaluate the effects of the xenoestrogen 4-n-nonylphenol (NP) in the prosobranch gastropod Patella caerulea, which exhibits protandrous hermaphroditism as its reproductive strategy. We isolated a partial sequence of a GnRH-like molecule from the gonads of Patella caerulea. The deduced amino acid sequence is highly homologous to that reported for the Lottia gigantea GnRH. Patella caerulea GnRH (pGnRH) mRNA expression is widespread in both male and female germ lines during gametogenesis. We suggest pGnRH as a novel biomarker for the early assessment of presence of EDCs and monitoring short and long-term impacts on Patella caerulea community structure.

机译：据报道，内分泌干扰化合物（EDCs）会干扰内分泌系统，模仿不同种类软体动物中性类固醇激素的作用。 Prosobranchs常被用作评估EDC暴露的可靠生物指标。在本文中，我们评估异种雌激素4-n-壬基酚（NP）在腹足前腹足纲Pat菜中的作用，Pat菜具有雌雄同体作为生殖策略。我们从Pat菜的性腺中分离出GnRH样分子的部分序列。推导的氨基酸序列与Lottia gigantea GnRH报道的氨基酸序列高度同源。在配子发生过程中，er菜GnRH（pGnRH）mRNA表达在雄性和雌性种系中广泛分布。我们建议将pGnRH作为一种新型生物标记物，用于早期评估EDC的存在并监测对short菜蓝藻群落结构的短期和长期影响。

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《Zoological Science》 |2013年第2期|共6页
作者
De Lisa Emilia; Carella Francesca; De Vico Gionata; Di Cosmo Anna;
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正文语种 eng
中图分类动物学;
关键词
GnRH-like molecule; biomarker; xenoestrogen; 4-n-nonylphenol (NP); prosobranch; Patella caerulea;

机译：GnRH样分子;生物标志物;异雌激素;4-正壬基酚（NP）;前分支;青P;

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1. The Gonadotropin Releasing Hormone (GnRH)-like Molecule in Prosobranch Patella caerulea: Potential Biomarker of Endocrine-disrupting Compounds in Marine Environments [J] . De Lisa Emilia, Carella Francesca, De Vico Gionata, Zoological Science . 2013,第2期

机译：Prosobranch Pat菜中的促性腺激素释放激素（GnRH）样分子：海洋环境中破坏内分泌的化合物的潜在生物标志物
2. Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression [J] . OlbergD.E., AndressenK.W., LevyF.O., Bioorganic and Medicinal Chemistry Letters . 2014,第7期

机译：小分子的合成和体外评价[18F]标记的促性腺激素 - 释放激素（GnRH）受体拮抗剂作为GnRH受体表达的潜在PET成像剂
3. Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression [J] . OlbergD.E., AndressenK.W., LevyF.O., Bioorganic and Medicinal Chemistry Letters . 2014,第7期

机译：小分子[18F]标记的促性腺激素释放激素（GnRH）受体拮抗剂的合成及其体外评价，可作为表达GnRH受体的潜在PET成像剂
4. Characterization and pharmacokinetic study of Sustained Release Microspheres containing Gonadotropin Releasing Hormone(GNRH) [C] . Deokkeun Lee, Nakhyun Lim, Seyeon Kim, Annual meeting exposition of the Controlled Release Society . 2011

机译：含促性腺激素释放激素（GNRH）的缓释微球的表征和药代动力学研究
5. Appetite regulation in winter flounder (Pseudopleuronectes americanus): characterization of melanin-concentrating hormone (MCH) and gonadotropin-releasing hormone (GnRH) transcript families and their role in feeding behaviour. [D] . Tuziak, Sarah. 2011

机译：冬季比目鱼（Pseudopleuronectes americanus）的食欲调节：黑色素浓缩激素（MCH）和促性腺激素释放激素（GnRH）转录本家族的特征及其在喂养行为中的作用。
6. Fanconi Anemia a Is a Nucleocytoplasmic Shuttling Molecule Required for Gonadotropin-Releasing Hormone (GnRH) Transduction of the GnRH Receptor [O] . Rachel Larder, Dimitra Karali, Nancy Nelson, -1

机译：范可尼贫血a是促性腺激素释放激素（GnRH）转导GnRH受体所需的核质穿梭分子
7. Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment [O] . Macklon N.S. (Nick), Eijkemans M.J.C. (René), Ludwig M. (Michael), 2003

机译：重组卵泡促性腺激素，重组黄体生成激素或促性腺激素释放激素（GnRH）激动剂给药后，在体外受精患者中接受重组卵泡刺激素和GnRH拮抗剂联合卵巢刺激后卵母细胞成熟，黄体期特征未得到补充
8. Estradiol Alters the Effectiveness of Gonadotropin-Releasing Hormone (GnRH) in Ovine Pituitary Cultures: GnRH Receptors versus Responsiveness to GnRH [R] . Laws, S. C., Webster, J. C., Miller, W. L. 1990

机译：雌二醇改变促性腺激素释放激素（GnRH）在绵羊垂体培养中的有效性：GnRH受体与对GnRH的反应

The Gonadotropin Releasing Hormone (GnRH)-like Molecule in Prosobranch Patella caerulea: Potential Biomarker of Endocrine-disrupting Compounds in Marine Environments

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