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首页> 外文期刊>Zoological Science >Recent Advances in the Understanding of Teleost Medaka Ovulation: The Roles of Proteases and Prostaglandins
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Recent Advances in the Understanding of Teleost Medaka Ovulation: The Roles of Proteases and Prostaglandins

机译：理解Teleost Medaka排卵的最新进展：蛋白酶和前列腺素的作用

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摘要

Ovulation is the process of liberating oocytes from the preovulatory follicles, and is observed in the ovaries of virtually all female vertebrate animals. Compared with mammalian species, there have been far fewer studies that address the ovulatory mechanisms of non-mammalian species. We have examined the molecular mechanism of follicle rupture during ovulation using the teleost model, medaka, or Oryzias latipes. Follicle rupture in medaka ovulation involves the cooperation of the tissue inhibitor of metalloproteinase-2b protein with at least three matrix metalloproteinases (MMP): membrane type-1 MMP (MT1-MMP), MT2-MMP, and gelatinase A. Our studies also indicate that the serine protease, i.e., plasmin, participates in the rupture for only a few hours prior to the activation of MMP-mediated hydrolysis at ovulation. The involvement of prostaglandin E-2 (PGE(2)) in medaka ovulation was also demonstrated. Cyclooxygenase-2 and PGE(2) receptor subtype EP4b were respectively shown to be an enzyme responsible for PGE(2) synthesis and a receptor for the generated ligand in the preovulatory follicles. Based on the results obtained from our studies of fish, we discuss the similarities and differences in vertebrate ovulation compared with mammalian species.
机译：排卵是从排卵前卵泡释放卵母细胞的过程，并且在几乎所有雌性脊椎动物的卵巢中都可以观察到。与哺乳动物物种相比，涉及非哺乳动物物种排卵机制的研究很少。我们已经使用硬骨鱼模型，medaka或Oryzias latipes检查了排卵过程中卵泡破裂的分子机制。青med排卵中的卵泡破裂涉及金属蛋白酶2b蛋白的组织抑制剂与至少三种基质金属蛋白酶（MMP）的合作：膜1型MMP（MT1-MMP），MT2-MMP和明胶酶A。我们的研究还表明丝氨酸蛋白酶即纤溶酶在排卵时激活MMP介导的水解之前仅参与几个小时。还证明了前列腺素E-2（PGE（2））参与青aka排卵。环氧合酶2和PGE（2）受体亚型EP4b分别是负责PGE（2）合成的酶和排卵前卵泡中产生的配体的受体。根据对鱼类研究的结果，我们讨论了与哺乳动物相比，脊椎动物排卵的异同。

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