• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Zoological Science >Peripheral Administration of Kiss1 Pentadecapeptide Induces Gonadal Development in Sexually Immature Adult Scombroid Fish
【24h】

Peripheral Administration of Kiss1 Pentadecapeptide Induces Gonadal Development in Sexually Immature Adult Scombroid Fish

机译：Kiss1 Pentadecapeptide的外围管理诱导性不成熟成年Scombroid鱼的性腺发育。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Kisspeptins have emerged as potent regulators of the reproductive brain-pituitary-gonad (BPG) axis. Our previous study demonstrated that the brain of the chub mackerel (Scomber japonicus), a scombroid fish, expresses two kisspeptin-encoding genes, kiss1 and kiss2, and exhibits sexually dimorphic expression profiles. Recent studies strongly suggest that teleost Kiss1 and Kiss2 precursors produce mature Kiss1-pentadecapeptides (Kiss1-15) and Kiss2-dodecapeptides (Kiss2-12), respectively. In light of the above, the present study evaluated the potency of synthetic peptides of Kiss1-15, Kiss2-12, and a GnRH analog (GnRHa) on inducing gonadal development in sexually immature adult chub mackerel. Synthetic peptides were administered subcutaneously through miniosmotic pumps. On day 45 post-administration, gonadosomatic index (GSI) values (%) of male fish treated with Kiss1-15 (1.82) significantly increased in comparison to initial control (0.33), final control (0.49), Kiss2-12 (0.24), and GnRHa (1.13)-treated fish. Interestingly, the testis of all Kiss1-15 treated fish revealed spermiation, and were full of spermatozoa. These fish showed significantly higher levels of pituitary fsh beta and lh beta mRNAs and circulating 11-ketotestosterone. GnRHa treated fish also revealed the presence of few spermatozoa in the testis. In females, no significant changes in GSI values were found between treatments; however, Kiss1-15-and GnRHa-treated fish showed prominent signs of vitellogenic onset, with many early yolk oocytes in their ovaries. Interestingly, Kiss1-15-treated fish exhibited higher levels of pituitary fsh beta and circulating estradiol-17 beta. These results indicate that peripheral administration of Kiss1-15 and GnRHa can induce gonadal development in sexually immature chub mackerel.
机译：Kisspeptins已成为生殖脑-垂体-性腺（BPG）轴的有效调节剂。我们之前的研究表明，鲭鱼（Scomber japonicus）的大脑是一种com类鱼类，它表达两个kisseptin编码基因kiss1和kiss2，并表现出性二态表达特征。最近的研究强烈表明，硬骨鱼Kiss1和Kiss2前体分别产生成熟的Kiss1-pentadecapeptides（Kiss1-15）和Kiss2-dodecapepteptides（Kiss2-12）。鉴于上述情况，本研究评估了Kiss1-15，Kiss2-12和GnRH类似物（GnRHa）的合成肽对性未成熟成年鱼鲭鱼的性腺发育诱导作用。通过微渗透泵皮下施用合成肽。与初始对照组（0.33），最终对照组（0.49）和Kiss2-12（0.24）相比，给药后第45天，用Kiss1-15（1.82）处理的雄鱼的性腺体激素指数（GSI）值（％）显着增加。和GnRHa（1.13）处理的鱼。有趣的是，所有用Kiss1-15处理的鱼的睾丸都显示出精子，并且充满了精子。这些鱼的垂体fsh beta和lh beta mRNA水平和循环中的11-酮睾酮水平均显着升高。经GnRHa处理的鱼还显示出睾丸中几乎没有精子。在女性中，治疗之间未发现GSI值有明显变化。但是，用Kiss1-15和GnRHa处理的鱼表现出明显的卵黄性发作迹象，卵巢中有许多早期卵黄卵母细胞。有趣的是，用Kiss1-15处理的鱼表现出较高水平的垂体fsh beta和循环雌二醇17 beta。这些结果表明，外围施用Kiss1-15和GnRHa可以诱导性未成熟鱼的性腺发育。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号