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首页> 外文期刊>Zoological Science >A Rapid Increase in cAMP in Response to 20-Hydroxyecdysone in the Anterior Silk Glands of the Silkworm, Bombyx mori
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A Rapid Increase in cAMP in Response to 20-Hydroxyecdysone in the Anterior Silk Glands of the Silkworm, Bombyx mori

机译：家蚕前丝腺中20-羟基蜕皮激素对cAMP的快速响应

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摘要

In the anterior silk glands (ASGs) of the silkworm, Bombyx mori, intracellular cAMP increases transiently to a very high level shortly after the hemolymph ecdysteroid peak in the prepupal period. In cultured ASGs obtained on the day of gut-purge, cAMP levels were increased by 20-hydroxyecdysone (20E), and this increase was enhanced by an inhibitor of phosphodiesterase, but was not affected by alpha-amanitin, indicating the 20E action may not be mediated via gene expression. The increase in cAMP occurred within 30 seconds of exposure to a physiological concentration of 20E (1 muM), and also by ponasterone A. Our findings indicate a nongenomic action of ecdysteroids in insects, which may be an additional mechanism by which this steroid hormone induces acute responses in tissues and cells.
机译：在家蚕的家蚕前腺（ASGs）中，胞浆内cAMP在ly前期的血淋巴蜕膜激素达到峰值后不久即瞬间升高到很高的水平。在肠道清洗当天获得的培养的ASG中，cAMP水平被20-羟基蜕皮激素（20E）升高，并且这种增加被磷酸二酯酶抑制剂增强，但不受α-amanitin的影响，表明20E作用可能不会通过基因表达介导。 cAMP的增加发生在暴露于20E（1μM）的生理浓度下的30秒内，并且也受ponasterone A的影响。我们的发现表明蜕皮类固醇在昆虫中具有非基因组作用，这可能是该类固醇激素诱导的另一种机制组织和细胞的急性反应。

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