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The Role of the Terminal Nerve and GnRH in Olfactory System Neuromodulation

机译：末端神经和GnRH在嗅觉系统神经调节中的作用

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摘要

Animals must regulate their sensory responsiveness appropriately with respect to their internal and external environments, which is accomplished in part via centrifugal modulatory pathways. In the olfactory sensory system, responsiveness is regulated by neuromodulators released from centrifugal fibers into the olfactory epithelium and bulb. Among the modulators known to modulate neural activity of the olfactory system, one of the best understood is gonadotropin-releasing hormone (GnRH). This is because GnRH derives mainly from the terminal nerve (TN), and the TN-GnRH system has been suggested to function as a neuromodulator in wide areas of the brain, including the olfactory bulb. In the present article we examine the modulatory roles of the TN and GnRH in the olfactory epithelium and bulb as a model for understanding the ways in which olfactory responses can be tuned to the internal and external environments.
机译：动物必须针对其内部和外部环境适当地调节其感官反应能力，这部分是通过离心调节途径来实现的。在嗅觉感觉系统中，反应性由从离心纤维释放到嗅觉上皮和球中的神经调节剂调节。在已知可调节嗅觉系统神经活动的调节剂中，最广为人知的一种是促性腺激素释放激素（GnRH）。这是因为GnRH主要来自末梢神经（TN），并且已建议TN-GnRH系统在包括嗅球在内的大脑广泛区域中充当神经调节剂。在本文中，我们研究了TN和GnRH在嗅觉上皮和球茎中的调节作用，以此作为模型来了解嗅觉反应可调节至内部和外部环境的方式。

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