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首页> 外文期刊>Zoological Science >Sex Differences in Behavioral and Corticosterone Responses to Mild Stressors in ICR Mice are Altered by Ovariectomy in Peripubertal Period
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Sex Differences in Behavioral and Corticosterone Responses to Mild Stressors in ICR Mice are Altered by Ovariectomy in Peripubertal Period

机译：在ICR小鼠中，行为和皮质酮对轻度应激源反应的性别差异在青春期后通过卵巢切除术得以改变

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Among rodents, females are generally considered to be highly responsive in terms of emotionality under stressful conditions, and have higher corticosterone levels and activity. In this study, we examined sex differences in mice by evaluating anxiety behaviors and corticosterone responses to mild stressors. In our first experiment, we analyzed the behavioral and corticosterone responses to the elevated plus-maze test and open-field test in male and female mice, and compared sex differences. Principal component analysis (PCA) was used to investigate the correlation of these responses between males and females. The corticosterone level was higher in females under both basal and stressed conditions. In the behavioral response, higher locomotor activity was seen in females in the elevated plus-maze test. PCA showed little association among anxiety behavior, locomotor activity, and corticosterone secretion. In our second experiment, we examined the activational effects of sex steroids on the corticosterone response to the elevated plus-maze test by gonadectomizing male and female mice and using testosterone or estrogen capsules as hormonal replacements. Sex differences at the basal corticosterone level were not altered by the hormonal milieu in adults, however the higher corticosterone level of females in response to stress was diminished by ovariectomy, although replacement with neither testosterone nor estrogen had any effect. These results suggest that the sex difference in novelty exposure observed in the form of a greater hypothalamic-pituitary-adrenal (HPA) axis response in female ICR mice is controlled by ovary-derived factors in adults.
机译：在啮齿动物中，通常认为雌性在压力条件下的情绪反应能力强，并且皮质酮水平和活性较高。在这项研究中，我们通过评估焦虑行为和皮质酮对轻度应激源的反应，检查了小鼠的性别差异。在我们的第一个实验中，我们分析了雄性和雌性小鼠对升高的迷宫测试和开放视野测试的行为和皮质酮反应，并比较了性别差异。主成分分析（PCA）用于调查男性和女性之间这些反应的相关性。在基础和压力条件下，女性的皮质酮水平较高。在行为反应中，在高迷宫测试中，女性的运动能力较高。 PCA在焦虑行为，自发活动和皮质酮分泌之间几乎没有关联。在我们的第二个实验中，我们通过对雄性和雌性小鼠进行性腺切除术并使用睾丸激素或雌激素胶囊作为荷尔蒙替代品，研究了性类固醇对皮质醇对升高的迷宫测试反应的激活作用。成年人的激素环境不会改变基础皮质激素水平的性别差异，但是通过卵巢切除术降低了女性对应激反应的较高皮质激素水平，尽管用睾丸激素和雌激素都没有替代作用。这些结果表明，成年女性卵巢来源的因子控制着雌性ICR小鼠下丘脑-垂体-肾上腺（HPA）轴反应增强形式的新颖性暴露中的性别差异。

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